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Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats.

机译：自然发生的雌激素 - 脂肪酸酯对雌性大鼠乳腺细胞生长和癌变的影响。

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Research work completed thus far: (1) We have already evaluated the stimulatory effects of estradiol-17 beta-stearate on the growth of mammary vs. uterine cells in ovariectomized female Sprague-Dawley rats. Their effects have been compared with the effects of unesterified estradiol. (2) We have also determined the circulating levels of prolactin, FSH, and LH in all the animals. Right now we are still studying the growth-stimulatory effects of estradiol-17 beta-stearate and unesterified estradiol in pituitary, thymus, and liver of female rats. (3) We have completed comparing the carcinogenic activity of estradiol-17 beta-stearate and estradiol mammary vs. uterine cells in female ACI rats. We have also compared and correlated the differential carcinogenic activity of these two classes of estrogens with their differential growth stimulatory effects in various target organs. The results of our studies sheds light on the physiologic and pathophysiologic roles of endogenously-formed estrogen-fatty acid esters in the body. Also, our findings may lead to the development of new strategies to mammary cancer prevention through inhibition of esterase-catalyzed release of bioactive estrogen.

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作者
Lee, W. J.;
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年度 2004
页码 1-7
总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Mammary glands; Fatty acid esters; Estrogens; Breast cancer; Oncogenesis; Hormones; Rats; Stearates; Uterus; Medical research; Growth(Physiology); Cells(Biology); Prevention; Carcinogenesis; Estradiol;

机译：乳腺;脂肪酸酯;雌激素;乳腺癌;肿瘤发生;激素;大鼠;硬脂酸;子宫;医学研究;生长（生理学）;细胞（生物学）;预防;癌变;雌二醇;

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1. Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz(a)anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats. [J] . Kitamura Y, Yamagishi M, Okazaki K, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2006,第2期

机译：缺乏对雌性Sprague-Dawley大鼠的7,12-二甲基苯并（a）蒽（DMBA）和1,2-二甲基肼（DMH）诱导的乳腺和结肠癌发生的化学预防作用。
2. Naturally-occurring estradiol-17beta-fatty acid esters, but not estradiol-17beta, preferentially induce mammary tumorigenesis in female rats: implications for an important role in human breast cancer. [J] . Mills LH, Yu J, Xu XM, Toxicology and Applied Pharmacology . 2008,第3期

机译：天然存在的雌二醇17β-脂肪酸酯而不是雌二醇17β优先诱导雌性大鼠的乳腺肿瘤发生：这对人类乳腺癌的重要作用具有重要意义。
3. Short-term pregnancy hormone treatment of N-methyl-N-nitrosourea-induced mammary carcinogenesis in relation to fatty acid composition of serum phospholipids in female Lewis rats. [J] . Lai YC, Hamazaki K, Yoshizawa K, In vivo. . 2010,第4期

机译：N-甲基-N-亚硝基脲诱导的乳腺癌致癌作用的短期妊娠激素治疗与雌性Lewis大鼠的血清磷脂脂肪酸组成有关。
4. IRF-1 Promotes Apoptosis in p53-damaged Basal-type Human Mammary Epithelial Cells: A Model for Early Basal-type Mammary Carcinogenesis [C] . Michelle L. Bowie, Catherine Ibarra, Victoria L. Seewal International Symposium on Hormonal Carcinogenesis . 2008

机译：IRF-1促进P53受损的基础型人乳腺上皮细胞凋亡：早期基础型乳腺发生模型
5. Studies on the effects of estrogen fatty acid esters on mammary cell growth and carcinogenesis in female rats. [D] . Mills, Laura Hook. 2003

机译：雌激素脂肪酸酯对雌性大鼠乳腺细胞生长和致癌作用的研究。
6. Lack of effect of colony-stimulating factors interleukins interferons and tumor necrosis factor on the growth and differentiation of cultured Reed-Sternberg cells. Comparison with effects of phorbol ester and retinoic acid. [O] . S. M. Hsu, P. L. Hsu 1990

机译：菌落刺激因子白介素干扰素和肿瘤坏死因子对培养的Reed-Sternberg细胞的生长和分化缺乏影响。与佛波酯和维甲酸的作用进行比较。
7. 2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth In vitro [O] . Zongjian Zhu, Weiqin Jiang, John N. McGinley, 2005

机译：2-脱氧葡萄糖作为能量限制性模拟剂：对乳腺癌的影响和体外乳腺肿瘤细胞生长
8. Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats [R] . Lee, W. J. , Zhu, B. T. , Mills, L. H. 2005

机译：自然发生的雌激素 - 脂肪酸酯对雌性大鼠乳腺细胞生长和癌变的影响

Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats.

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