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首页> 美国政府科技报告 >Simultaneous Determination of Cocaine, Cocaethylene, and Their Possible Pentafluoropropylated Metabolites and Pyrolysis Products by Gas Chromatography/ Mass Spectrometry
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Simultaneous Determination of Cocaine, Cocaethylene, and Their Possible Pentafluoropropylated Metabolites and Pyrolysis Products by Gas Chromatography/ Mass Spectrometry

机译：气相色谱/质谱法同时测定可卡因，可可乙烯及其可能的五氟丙基化代谢物和热解产物

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During the investigation of fatal transportation accidents, samples from victims are also analyzed for drugs including cocaine (COC), COC is abused by smoking, nasal insufflantion, and intravenous injection, and it is also taken with ethanol. Therefore, it is important to determine concentrations of COC and its metabolites ethanol analogs, and pyrolysis products for establishing the degree of toxicity that possible ingestion of ethanol, and the possible route of administration. In this study a sensitive and selective procedure is developed for the simultaneous analyses of COC, benzoylecgonine norbenzoylecgonine norcocaine, ecgonine ecgonine ethyl ester, in blood, urine, and muscle homogenate. In the analysis, available deuterated analogs of these analytes were used as internal standards. Proteins from blood and muscle homogenate were precipitated with cold acetonitrile. After the removal of acetonitrile by evaporation the supernatants and urine were extracted by solid-phase chromatography. The eluted analytes were converted to hydrochloride salts and derivatized with pentafluoropropionic anhydride and 2,2,3,3,3-pentafluoro-1 propanol.

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