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Increasing Mammographic Breast Density in Response to Hormone Replacement Therapy and Breast Cancer Risk

机译：增加乳腺摄影乳腺密度以响应激素替代疗法和乳腺癌风险

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Hormone replacement therapy (HRT) use is associated with a small increased risk of developing breast cancer. Currently, it is not possible to predict which women using HRT are at increased risk of developing breast cancer. HRT causes an increase in mammographic density in 17-37% of women. Women with increased mammographic density are also known to be at increased risk for developing breast cancer. We therefore hypothesize that women who have an increase in mammographic density in response to HRT. The purpose of this case- control study is to determine if an increase in mammographic density in response to HRT is associated with an increased risk of breast cancer. Breast cancer cases at our institution between 1990-2000 will be evaluated, identifying postmenopausal women using HRT at the time of diagnosis. These women will be matched (1:2, case: control) by age and year of mammogram. Clinical data will be collected. Change in breast density over time will be assessed using quantitative digital analysis. Odds ratios will estimate the association between HRT-associated increase in breast density and risk of breast cancer.

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