首页> 美国政府科技报告 >Involvement of Tyrosine Phosphatses in Insulin Signaling and Apoptosis in Breast Cancer; Final rept. 1 Jun 2000-31 May 2003

【24h】

Involvement of Tyrosine Phosphatses in Insulin Signaling and Apoptosis in Breast Cancer; Final rept. 1 Jun 2000-31 May 2003

机译：酪氨酸磷酸酶参与乳腺癌胰岛素信号传导和细胞凋亡;最终的评论。 2000年6月1日至2003年5月31日

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Breast cancer incidence is highest in caucasian women lowest in American Indian women but these trends are reversed for type 2 diabetes. We hypothesized that distinctions in insulin load and signaling may play a role in both diseases and investigated the role of a tyrosine phosphatase PTP1B previously reported to be a regulator of both insulin signaling and breast cancer. We noted that calcium flux into breast cancer cells suppressed tyrosine phosphorylation and induced partial proteolysis of PTP1B resulting in liberation of PTP1B from its membranous anchor. To investigate the role of the cytoplasmic form of PTP1B (tPTP1B) in breast cancer cells we expressed it and various mutants (phosphatase-dead substrate-trap) in breast cancer cells under control of an inducible promoter. Unexpectedly, tPTP1B did not suppress insulin signaling but targeted phosphorylated HER2 suppressing its signaling. Our results suggest that activation of PTP1B by its partial proteolysis targets HER2 an oncogene common in aggressive breast cancer and modulation of PTP1B proteolysis through calcium flux may be a unique approach in treatment or prevention of breast cancer.

著录项

作者
Donato, N. J.;
展开▼
作者单位

展开▼
年度 2003
页码 p.1-16
总页数 16
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Breast cancer; Membranes(Biology); Cells(Biology); Women; Apoptosis; Tyrosine; Peptide hydrolases; Caucasians; American Indians; Mutations; Calcium; Insulin;

机译：乳腺癌;膜（生物学）;细胞（生物学）;妇女;细胞凋亡;酪氨酸;肽水解酶;高加索人;美洲印第安人;突变;钙;胰岛素;

相似文献

外文文献
中文文献
专利

1. Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer [J] . Xihong Zhang, Douglas Yee Breast Cancer Research . 2000,第3期

机译：乳腺癌中的酪氨酸激酶信号传导：乳腺癌中胰岛素样生长因子及其受体
2. Tyrosine kinase signalling in breast cancer: Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates [J] . Rania Kairouz, Roger J Daly Breast Cancer Research . 2000,第3期

机译：乳腺癌中的酪氨酸激酶信号转导：通过改变信号中间体的表达来调节人乳腺癌中的酪氨酸激酶信号转导
3. Baicalin Induces Apoptosis and Inhibits Migration/Invasion of Breast Cancer Cell MDA-MB-231 Through Reactive Oxygen Species-Mediated Activation of p38/c-Jun N-Terminal Kinase Signaling Pathway [J] . Zhang Huayong, Huang Xinfeng, Li Qiaomin, Journal of biomaterials and tissue engineering . 2018,第7期

机译：黄芩苷通过反应性氧物种介导的P38 / C-JUN N-末端激酶信号通路的活性诱导细胞凋亡并抑制乳腺癌细胞MDA-MB-231的迁移/侵袭
4. Involvement of AMPK Signaling Cascade in Capsaicin-Induced Apoptosis of HT-29 Colon Cancer Cells [C] . YOUNG MIN KIM, JIN-TAEK HWANG, DONG WOOK KWAK, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：AMPK信号级联参与辣椒素诱导的HT-29结肠癌细胞凋亡。
5. The effect of hypoglucose on cardiac apoptosis: Insulin signaling pathway and c -Jun N -terminal kinase function. [D] . Li, Huifang. 2006

机译：低葡萄糖对心脏细胞凋亡的影响：胰岛素信号通路和c -Jun N-末端激酶功能。
6. Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer [O] . Xihong Zhang, Douglas Yee 2000

机译：乳腺癌中的酪氨酸激酶信号转导：乳腺癌中胰岛素样生长因子及其受体
7. Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer [O] . Zhang Xihong, Yee Douglas 2000

机译：乳腺癌中的酪氨酸激酶信号转导：乳腺癌中胰岛素样生长因子及其受体

Involvement of Tyrosine Phosphatses in Insulin Signaling and Apoptosis in Breast Cancer; Final rept. 1 Jun 2000-31 May 2003

摘要

著录项

相似文献

相关主题

期刊订阅