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Telomerase Induction of TGF(beta) Resistant Growth in Cultured Human Mammary Epithelial Cells

机译：端粒酶诱导培养的人乳腺上皮细胞中TGF（β）抗性生长

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The failures to growth arrest in response to critically short telomeres or to TGFbeta are key derangements- thought -to contribute to the inappropriate cell growth that characterizes breast cancer progression. Our recent observations indicate that activation of telomerase activity may be directly involved in overcoming both inhibitory pathways in human mammary epithelial cells (HMEC). By exploring the common thread connecting telomerase expression and resistance to TGFBeta growth inhibition, it may be possible to unify two divergent areas of significance for breast cancer development and treatment We have begun to dissect the complex mechanisms responsible for these changes in expectation that such knowledge may enable us to prevent or reverse them. We have found that in addition to abrogation of TGFBETA-mediated growth arrest, high telomerase expression is also able to partially interfere with growth arrest due to blockage of EGF receptor signal transduction. The PI3K pathway appears to be necessary for this effect, and may either interact cooperatively with a telomerase influenced pathway or may act downstream of telomerase. We have examined several molecules involved in cell cycle regulation, and are presently exploring a promising new lead suggesting that telomerase may exert its effects indirectly through a p53-dependent pathway.

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Yaswen, P.;
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年度 2002
页码 1-17
总页数 17
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Epithelium; Cells(Biology); Sense organs; Resistance(Biology); Breast cancer; Humans; Molecules; Arresting(Process); Cycles; Transducers; Inhibition; Mammary glands; Growth(Physiology);

机译：上皮;细胞（生物学）;感觉器官;抵抗（生物学）;乳腺癌;人类;分子;逮捕（过程）;周期;转导者;抑制;乳腺;生长（生理学）;

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1. Activation of p53, inhibition of telomerase activity and induction of estrogen receptor beta are associated with the anti-growth effects of combination of ovarian hormones and retinoids in immortalized human mammary epithelial cells [J] . Jiahui Zhang, Yifan Tu, Sallie Smith-Schneider Cancer Cell International . 2005,第1期

机译：p53的激活，端粒酶活性的抑制和雌激素受体β的诱导与卵巢激素和类维生素A组合在永生化的人乳腺上皮细胞中的抗生长作用有关
2. EW‐7203, a novel small molecule inhibitor of transforming growth factor‐β (TGF‐β) type I receptor/activin receptor‐like kinase‐5, blocks TGF‐β1‐mediated epithelial‐to‐mesenchymal transition in mammary epithelial cells [J] . Chul-Yong Park, Dae-Kee Kim Cancer science. . 2011,第10期

机译：EW-7203是一种新型的转化生长因子-β（TGF-β）I型受体/激活素受体样激酶-5的新型小分子抑制剂，可阻断TGF-β1介导的乳腺上皮细胞的上皮-间质转化
3. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. [J] . Erdogan M, Pozzi A, Bhowmick N, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2008,第15期

机译：R-Ras介导的乳腺上皮细胞转化需要转化生长因子-β（TGF-beta）和TGF-β相关的激酶1。
4. Cell-Type-Dependent Effect of Transforming Growth Factor-beta, a Major Cytokine in Breast Milk, on Human Immunodeficiency Virus Type 1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages [C] . M. Moriuchi, H. Moriuchi International AIDS Conference . 2004

机译：转化生长因子-β，母乳中主要细胞因子的细胞型依赖性效应，对人免疫缺陷病毒1型感染乳腺上皮MCF-7细胞或巨噬细胞
5. TGF-beta promotes cancer progression through the xIAP:TAB1:TAK1:IKK axis in mammary epithelial cells. [D] . Neil, Jason Robert. 2008

机译：TGF-β通过xIAP：TAB1：TAK1：IKK轴促进乳腺上皮细胞中的癌症进展。
6. Activation of p53 inhibition of telomerase activity and induction of estrogen receptor beta are associated with the anti-growth effects of combination of ovarian hormones and retinoids in immortalized human mammary epithelial cells [O] . Jiahui Zhang, Yifan Tu, Sallie Smith-Schneider 2005

机译：p53的激活端粒酶活性的抑制和雌激素受体β的诱导与卵巢激素和类维生素A组合在永生化的人乳腺上皮细胞中的抗生长作用有关
7. Activation of p53, inhibition of telomerase activity and induction of estrogen receptor beta are associated with the anti-growth effects of combination of ovarian hormones and retinoids in immortalized human mammary epithelial cells [O] . Smith-Schneider Sallie, Tu Yifan, Zhang Jiahui 2005

机译： p53 的激活，端粒酶活性的抑制和雌激素受体β的诱导与卵巢激素和类维生素A组合在永生化的人乳腺上皮细胞中的抗生长作用有关

Telomerase Induction of TGF(beta) Resistant Growth in Cultured Human Mammary Epithelial Cells

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