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Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging

机译:扩散加权磁共振成像预测乳腺肿瘤恶性程度

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The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measured by a completely non-invasive MRI method. This hypothesis is being tested by: (1) The design and construction of ultra-high gradient coils for MRI. (2) The implementation of advanced MRI pulse sequences for mapping of microvascular parameters (3) The correlation of MRI-derived vascular parameters (diffusion and perfusion) with histological parameters (tumor grade and microvessel density) in an animal model of human breast cancer.

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