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Benzo(a)pyrene-Induced Immune Alteration in the Japanese Medaka Oryzias Latipes: Probing the Underlying Cellular Mechanisms

机译：Benzo（a）芘诱导的日本medaka Oryzias Latipes免疫改变：探索潜在的细胞机制

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Increasing public concerns regarding the use of mammals in toxicological studies have led researchers to seek 'alternative models' to investigate the biological effects of xenobiotics. Due to its small size and adaptability to a laboratory environment, the Japanese medaka (Oryzias latipes) lends itself well to such studies. Although medaka are used routinely for carcinogenicity testing, little emphasis has been placed upon this species for assessing the immunotoxic effects of chemicals. Given the known effects of benzo(a)pyrene (BaP) on the immune system of mammals, studies were conducted using medaka to examine the effects and cellular mechanisms by which exposure to BaP might alter the immune status of this laboratory fish model. Results demonstrated that IP treatment with BaP suppressed medaka lymphocyte proliferation, T-lymphocyte dependent antibody-forming cell (AFC) numbers, and phagocyte intracellular superoxide production. Thus, exposure of medaka to BaP resulted in suppression of both innate and adaptive immune parameters. Additional experiments demonstrated induction of CYPlA expression and activity within kidney tubules and mononuclear immune cells, indicating that medaka immune organs/cells are capable of metabolizing BaP into immunotoxic metabolites in situ.

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Carlson, E. A.;
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年度 2002
页码 1-367
总页数 367
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
T lymphocytes; Immunity; Fishes; Hosts(Biology); Toxicology; Test and evaluation; Environments; Mammals; Chemicals; Parameters; Toxicity; Japan; Adaptive systems; Laboratories; Exposure(Physiology); Response(Biology); Immunology; Carcinogens; Cells(Biology); Suppression; Organs(Anatomy); Cytology;

机译：T淋巴细胞;免疫;鱼类;宿主（生物学）;毒理学;测试和评估;环境;哺乳动物;化学品;参数;毒性;日本;适应系统;实验室;暴露（生理学）;反应（生物学）;免疫学;致癌物;细胞（生物学）;抑制;器官（解剖学）;细胞学;

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专利

1. Benzo(a)pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression. [J] . Carlson EA, Li Y, Zelikoff JT Toxicology and Applied Pharmacology . 2004,第1期

机译：苯并（a）-诱导的日本（Oryzias latipes）免疫毒性：淋巴CYP1A活性与体液免疫抑制之间的关系。
2. Potential mechanisms underlying embryonic developmental toxicity caused by benzo[a]pyrene in Japanese medaka (Oryzias latipes) [J] . Yamaguchi Akemi, Uchida Masaya, Ishibashi Hiroshi, Chemosphere . 2020,第Mara期

机译：苯并[a]芘在日本Medaka（Oryzias LaTipes）引起的胚胎发育毒性的潜在机制
3. Protective effects of green tea polyphenols against benzo[a]pyrene-induced reproductive and trans-generational toxic effects in Japanese Medaka (Oryzias latipes) [J] . Song Chuankui, Wang Yanli, Xiao Zhengcao, Journal of Functional Foods . 2015,第Null期

机译：绿茶多酚对苯并[a]-诱导的生殖和跨代毒性效应的保护作用，在日本Medaka（Oryzias latipes）中
4. Influences of Temperature, pH and Turbidity on the Behavioral Responses of Daphnia magna and Japanese Medaka (Oryzias latipes) in the Biomonitor [C] . Linlin Chen, Xiue Fu, Gaosheng Zhang Biennial ISEM Conference on Ecological Modelling for Global Change and Coupled Human and Natural System . 2013

机译：温度，pH与浊度对Daphnia Magna和日本Medaka（Oryzias Lavipes）的行为应答的影响
5. Benzo[a]pyrene-induced immune alteration in the Japanese medaka Oryzias latipes: Probing the underlying cellular mechanisms. [D] . Carlson, Erik A. 2002

机译：苯并[a] py诱导的日本medaka Oryzias latipes免疫改变：探究潜在的细胞机制。
6. Interleukin-17A/F1 Deficiency Reduces Antimicrobial Gene Expression and Contributes to Microbiome Alterations in Intestines of Japanese medaka (Oryzias latipes) [O] . Yo Okamura, Natsuki Morimoto, Daisuke Ikeda, 2020

机译：白介素-17A / F1缺乏症会降低日本（Oryzias latipes）肠道中的抗菌素基因表达并促进微生物组变化。
7. Mechanisms of Selenomethionine Developmental Toxicity and the Impacts of Combined Hypersaline Conditions on Japanese Medaka (Oryzias latipes) [O] . Allison Kupsco, Daniel Schlenk 2014

机译：Selenomethionine发育毒性的机制及其组合高氧化碱条件对日本Medaka（Oryzias LaTipes）的影响

Benzo(a)pyrene-Induced Immune Alteration in the Japanese Medaka Oryzias Latipes: Probing the Underlying Cellular Mechanisms

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