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Investigation of the Stoichiometry of Na+ Cotransport with Dopamine in Rat and Human Dopamine Transporters Expressed in Human Embryonic Kidney Cells

机译：多巴胺对人胚肾细胞表达大鼠和人多巴胺转运体Na +协同转运的化学计量学研究

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摘要

The neuronal membrane transporter for dopamine (DAT) is a member of the Na+ and Cl dependent family of transporters and concentrates dopamine intracellularly up to 106 fold over extracellular levels. NY is hypothesized to provide the major driving force for this concentrative property. In order to validate the Na+-gradient hypothesis, it must be shown that NY accumulates in stoichiometric amounts along with the substrate.

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作者
Schumacher, P. D.;
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年度 2001
页码 1-86
总页数 86
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Nerve cells; Embryos; Dopamine; Theses; Substrates; Membranes; Cells(Biology); Stoichiometry; Force(Mechanics); Kidneys;

机译：神经细胞;胚胎;多巴胺;论文;基质;膜;细胞（生物学）;化学计量学;力（力学）;肾脏;

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专利

1. Advantages of heterologous expression of human D2long dopamine receptors in human neuroblastoma SH-SY5Y over human embryonic kidney 293 cells. [J] . AlbertsGL, PregenzerJF, ImWB British Journal of Pharmacology . 2000,第3期

机译：与人胚胎肾293细胞相比，人D2long多巴胺受体在人神经母细胞瘤SH-SY5Y中异源表达的优势。
2. Nitric oxide inhibits uptake of dopamine and N-methyl-4-phenylpyridinium (MPP~+ ) but not release of MPP~+ in rat C6 glioma cells expressing human dopamine transporter [J] . Bo-Jin Cao, Maarten E.A. Reith British Journal of Pharmacology . 2002,第8期

机译：一氧化氮抑制表达人多巴胺转运蛋白的大鼠C6胶质瘤细胞中多巴胺和N-甲基-4-苯基吡啶鎓（MPP〜+）的摄取，但不释放MPP〜+。
3. Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine. [J] . Ho M, Segre M Brain research . 2000,第1a2期

机译：稳定表达人多巴胺转运蛋白的小鼠神经母细胞瘤N1E-115细胞对多巴胺的摄取被模仿可卡因构型的抗独特型ab2beta抗体差异抑制。
4. EVALUATION OF THE TRANSCELLULAR TRANSPORT OF CERIVASTATIN ACROSS A DOUBLE-TRANSFECTED MDCKII CELL MONOLAYER EXPRESSING HUMAN OATP2 (UPTAKE TRANSPORTER) AND MRP2 (EFFLUX TRANSPORTER): A NEW SCREENING SYSTEM FOR TRANSEPITHELIAL TRANSPORT OF DRUGS [C] . S. Matsushima, K. Maeda, Y. Shitara, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：跨人表达人OATP2（摄取转运蛋白）和MRP2（外排转运蛋白）的双通道MDCKII细胞单层转运中西立伐他汀跨细胞转运的评估：药物经皮转运的新筛选系统
5. Factors that influence the dopamine neuron as revealed by dopamine transporter expression. [D] . Burke, Mark. 2005

机译：多巴胺转运蛋白表达揭示了影响多巴胺神经元的因素。
6. Advantages of heterologous expression of human D2long dopamine receptors in human neuroblastoma SH-SY5Y over human embryonic kidney 293 cells [O] . Glen L Alberts, Jeffrey F Pregenzer, Wha Bin Im 2000

机译：人神经母细胞瘤SH-SY5Y中人D2long多巴胺受体异源表达优于人胚胎肾293细胞的优势
7. Advantages of heterologous expression of human D2long dopamine receptors in human neuroblastoma SH-SY5Y over human embryonic kidney 293 cells [O] . Alberts, Glen L, Pregenzer, Jeffrey F, Im, Wha Bin 2000

机译：人神经母细胞瘤SH-SY5Y中人D2long多巴胺受体异源表达优于人胚胎肾293细胞的优势

Investigation of the Stoichiometry of Na+ Cotransport with Dopamine in Rat and Human Dopamine Transporters Expressed in Human Embryonic Kidney Cells

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