• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Biological and Clinical Significance of Androgen Receptor Variants.
【24h】

Biological and Clinical Significance of Androgen Receptor Variants.

机译：雄激素受体变异的生物学和临床意义。

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We achieved all of aims proposed for this project. Aim 1 was to evaluate AR-V7 as a prognostic marker in high-grade prostate cancer (PCa). We found that AR-V7 levels did not predict biochemical recurrence (BCR). Aim 2 was to determine whether AR-V7 levels in lowgrade PCa were prognostic, or predicted concurrent presence of high-grade PCa. We found that neither was the case. However, we did find that the ratio of AR-V1:AR-V7 was higher in low- grade PCa without concurrent high-grade PCa. Since AR-Vl reportedly blocks constitutive androgen signaling of AR-V7, this suggests that activity of AR-V7 in lowgrade PCa might be associated with development of high-grade Pea. Aim 3 was to evaluate the role of AR-V7 in mediating primary castration-resistant PCa (CRPC) in a tumorgraft model. We successfully established tumorgrafts from primary PCa and observed the development of CRPC and androgen- independent gene expression; however, we were unable to correlate AR-V7 levels with development of CRPC.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号