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Simulation of Action Potential Propagation Block on a Bidimensional Ventricular Tissue Model During Regional Myocardial Ischaemia.

机译：局部心肌缺血时二维心室组织模型动作电位传播模拟。

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During the acute phase of myocardial ischemia, electrophysiological alterations in ventricular cells exacerbate serious arrhythmias such as reentries. Indeed, extracellular potassium accumulation in an ischemic zone reduces conduction velocity. Concomitantly, the activation of ATP dependent potassium current (I sub k(sub ATP)) under ischemic conditions provokes a reduction in action potential duration (APD), creating inhomogeneities within the tissue, which represent the main cause of unidirectional block and reentry. In this work, we investigate the patterns of activation in an isotropic ischemic bidimensional tissue by means of computer simulations. Using the Luo-Rudy phase II model of ventricular action potential and the I sub k (sub ATP) formulation, we stimulated prematurely a bidimensional tissue of 5 cm2 with a normal zone. an ischemic zone and a border zone at different instants of time, to reproduce realistic conditions of reentry. Our results agree with experimental works and show the existence of a time interval (window of block), in which propagation is blocked in the central zone of ischaemia.

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Trenor, B.; Ferroro, J. M.; Montilla, F.;
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年度 2001
页码 1-5
总页数 5
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Meetings; Electrophysiology; Ischemia; Mathematical models; Spain; Cells(Biology); Potassium; Myocardium; Arrhythmia; Ventricles; Foreign reports;

机译：会议;电生理学;缺血;数学模型;西班牙;细胞（生物学）;钾;心肌;心律失常;心室;外国报告;

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1. Propagation of normal beats and re-entry in a computational model of ventricular cardiac tissue with regional differences in action potential shape and duration [J] . Clayton RH, Holden AV Progress in Biophysics and Molecular Biology: An International Review Journal . 2004,第2a3期

机译：正常搏动的传播和再进入在具有动作电位形状和持续时间区域差异的心室心脏组织计算模型中
2. Simulation of Action Potential Propagation in Cardiac Ventricular Tissue Using an Efficient PDE Model [J] . S. H Sabzpoushan, Alireza Faghani Ghodrat American Journal of Biomedical Engineering . 2012,第1期

机译：使用有效的PDE模型模拟心室组织中动作电位的传播
3. Modeling excitation and propagation of action potentials across inhomogeneous ventricular tissue [J] . Z. Li, A. V. Holden, C. H. Orchard, International journal of bifurcation and chaos in applied sciences and engineering . 2003,第12期

机译：模拟跨不均匀心室组织的动作电位的激发和传播
4. Simulation of action potential propagation block on a bidimensional ventricular tissue model during regional myocardial ischaemia [C] . Trenor, B., Ferrero, Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE . 2001

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Simulation of Action Potential Propagation Block on a Bidimensional Ventricular Tissue Model During Regional Myocardial Ischaemia.

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