Computer Simulation of Electrical Propagation in Cardiac Tissue.

机译：心脏组织电传播的计算机模拟。

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The purpose of the present research is to analyze the behavior of the reentrant spiral wave, which is one of the main causes of sudden cardiac death using computer simulation models of cardiac excitation propagation. The simulation model is a two dimensional electric circuit network model where many electric circuit models of cardiac membrane action potential were connected with electric resistance standing for intra-and extra cellular conductance. As cardiac membrane action potential model, we used Beeler-Reuter (B-R) model and Luo-Rudy (L-R) model. In order to investigate the effect of ionic current modification by anti-arrhythmic drugs on the reentrant pattern, we controlled the sodium current, I(sub Na), and the potassium current, I(sub K1), of the cardiac action potential models and investigated the obtained reentrant patterns. In order to validate the simulation results, we are comparing the reentry pattern under dose of anti-arrhythmic drugs observed by a high- resolution optical mapping system.

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Arafune, T.; Mishima, A.; Kobayashi, E.; Sakuma, I.; Inada, H.;
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年度 2001
页码 1-5
总页数 5
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Meetings; Computerized simulation; Electric current; Heart; Excitation; Mapping; Arrhythmia; Cardiovascular agents; Foreign reports;

机译：会议;计算机模拟;电流;心脏;激发;测绘;心律失常;心血管药物;外国报道;

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1. Effects of barriers on propagation of action potentials in two-dimensional cardiac tissue. A computer simulation study. [J] . Maglaveras N, Offner F, van Capelle FJ, Journal of Electrocardiology: An International Publication for the Study of the Electrical Activities of the Heart . 1995,第1期

机译：屏障对二维心脏组织中动作电位传播的影响。计算机仿真研究。
2. Effects of barriers on propagation of action potentials in two-dimensional cardiac tissue. A computer simulation study. [J] . Maglaveras N, Offner F, van Capelle FJ, Journal of Electrocardiology: An International Publication for the Study of the Electrical Activities of the Heart . 1995,第1期

机译：屏障对二维心脏组织中动作电位传播的影响。计算机仿真研究。
3. Simulation of propagation along a cylindrical bundle of cardiac tissue. II. Results of simulation [J] . Henriquez C.S., Plonsey R. IEEE Transactions on Biomedical Engineering . 1990,第9期

机译：沿心脏组织的圆柱形束传播的模拟。二。模拟结果
4. 3D parallel computer simulations of cardiac electrical propagation with sub-cellular resolution [C] . Pergola, N.F., Buchanan, . 1997

机译：具有亚细胞分辨率的心脏电传播的3D并行计算机模拟
5. Instability of cardiac excitation wave propagation and intracellular calcium dynamics (computer simulation study). [D] . Chudin, Eugene. 1999

机译：心脏激发波传播的不稳定性和细胞内钙动力学（计算机模拟研究）。
6. The Visible Human Dataset for the Simulation of the Cardiac Electrical Activity Propagation [O] . Paolo Valenza, Francesco Pinciroli 1995

机译：可见的人类数据集用于模拟心脏电活动的传播
7. High performance computer simulations of cardiac electrical function based on high resolution MRI datasets [O] . Plotkowiak, M, Rodriguez, B, Plank, G, 2008

机译：基于高分辨率MRI数据集的心脏电功能的高性能计算机仿真

Computer Simulation of Electrical Propagation in Cardiac Tissue.

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