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Noninvasive Intracranial Volume and Pressure Measurements Using Ultrasound

机译：使用超声波进行无创颅内容积和压力测量

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Prevention of secondary brain injuries following head trauma can be accomplished most easily when intracranial pressure (ICP) is monitored. However, current measurement techniques are invasive and thus not practical in the combat environment. The Pulsed Phase Lock Loop (PPLL) device, which was developed and patented by collaborators Dr. Yost and Dr. Cantrell, uses a unique, noninvasive ultrasonic phase comparison method to measure slight changes in cranial volume which occur with changes in ICP. The clinical application of such an instrument has significant challenges and described studies were designed to characterize, validate, and modify the equipment and measurement procedures. Experiments were performed in-vitro to simulate the clinical environment, in cadavers to understand further the clinical considerations, and in vivo to initiate clinical applications. The steps provide an important foundation for the development of a compact, noninvasive device for monitoring changes in intracranial distance. Clinical application may aid in the early detection of elevated ICP, decreasing risk of secondary brain injury and infection, and improved assessment of head- injured patients for additional medical evaluation or their ability to return to duty.

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