首页> 美国政府科技报告 >Expression and Function of Heat Shock Proteins in the Mammalian Gut During Experimentally Induced Hypoxia and Exogenous Stress
【24h】

Expression and Function of Heat Shock Proteins in the Mammalian Gut During Experimentally Induced Hypoxia and Exogenous Stress

机译:热休克蛋白在哺乳动物肠道实验性缺氧和外源性应激过程中的表达和功能

获取原文

摘要

The research was focused on characterization of the role of heat shock proteins during exogenous stress using mouse as model. The results of experiments provided evidence that heat shock protein 25 (Hsp25) maybe a specific factor protecting neuromuscular system from stress and stimulating subsequent regeneration. Hsp25 was specifically expressed in lower cholinergic motorneurons in normal conditions and was rapidly induced after heat shock and hypoxia..Hsp25 was colocalized with p38 and AKT kinases in the same cells. Specific p38 kinase inhibitor blocked expression of Hsp25 during regeneration. p38/AKT/Hsp25 cascade of signaling is critical for cell recovery.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号