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Fidelity of DNA Replication in Normal and Malignant Human Breast Cells

机译：正常和恶性人乳腺细胞中DNa复制的保真度

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In order to determine the degree to which the accumulation of mutations in breast cancer cells is due to a change in the fidelity of the cellular DNA replication machinery we have completed a series of experiments utilizing the multiprotein DNA synthesome isolated from malignant (cell culture and human tumors) and non-malignant (cell culture, benign human breast disease tissue, and disease-free human breast tissue) breast cells. The DNA synthesome has been extensively demonstrated to carry out full length DNA replication in vitro, and to accurately depict the DNA replication process as it occurs in the intact cell. By examining the fidelity of the DNA replication process carried out by the DNA synthesome from a number of breast cell types, we have demonstrated for the first time, that the cellular DNA replication machinery of malignant human breast cells is significantly more error-prone than that of non- malignant human breast cells.

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作者
Sekowski, J. W.;
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年度 1998
页码 1-44
总页数 44
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Deoxyribonucleic acids; Breast cancer; Tissues(Biology); Proteins; Mutations; Cells(Biology); Cultures(Biology); Mammary glands; Germ free animals;

机译：脱氧核糖核酸;乳腺癌;组织（生物学）;蛋白质;突变;细胞（生物学）;培养物（生物学）;乳腺;无菌动物;

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专利

1. Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells [J] . E. Dogliotti, F. Palombo, M. Bignami, Nucleic acids research . 1992,第24期

机译：与人类细胞中N-甲基-N-亚硝基脲诱导的DNA损伤相反的前导DNA链和落后DNA链的复制保真度
2. Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells [J] . E. Dogliotti, F. Palombo, M. Bignami, Nucleic acids research . 1992,第24期

机译：与人类细胞中N-甲基-N-亚硝基脲诱导的DNA损伤相反的前导DNA链和落后DNA链的复制保真度
3. Fidelity of deoxyribonucleic acid polymerases from normal and leukaemic human cells in polydeoxynucleotide replication [J] . B. I. Sahai Srivastava The biochemical journal . 1974,第2期

机译：正常人和白血病人细胞中的脱氧核糖核酸聚合酶在多脱氧核苷酸复制中的保真度
4. Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells [C] . N. Iwakuma, P. Sharma, M. J. Delano, Nano Science and Technology Institute(NSTI) Nanotechnology Conference and Trade Show(NSTI Nanotech 2007) vol.2; 20070520-24; Santa Clara,CA(US) . 2007

机译：人乳腺癌细胞和正常人乳腺癌上皮细胞对PEG-Silica-FITC纳米颗粒的摄取差异
5. Modulation and cellular distribution of O6-alkylguanine-DNA-alkyltransferase in normal and malignant human tissues [D] . Lee, Siow Ming. 1994

机译：正常和恶性人体组织中O6-烷基鸟嘌呤-DNA-烷基转移酶的调节和细胞分布
6. Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells [O] . Hua Du, Jiapeng Leng, Pengcheng Wang, 2018

机译：烟草特有的亚硝胺衍生的DNA加合物对人类细胞中DNA复制的效率和保真度的影响
7. Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells. [O] . Basic-Zaninovic, T, Palombo, F, Bignami, M, 1992

机译：与人类细胞中N-甲基-N-亚硝基脲诱导的DNA损伤相反的前导DNA链和落后DNA链的复制保真度。

Fidelity of DNA Replication in Normal and Malignant Human Breast Cells

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