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首页> 美国政府科技报告 >Dynamic Characteristics of Silver Nanoparticles in Physiological Fluids: Toxicological Implications.
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Dynamic Characteristics of Silver Nanoparticles in Physiological Fluids: Toxicological Implications.

机译：生理流体中银纳米粒子的动态特征：毒理学意义。

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The field of nanotoxicology has made tremendous progress identifying novel and potentially adverse biological effects observed following nanomaterial (NM) exposure. However, one facet yet to be satisfactorily explored is how a physiological environment modifies NM physicochemical properties, thus introducing new and dynamic complexities involving solid phase material exposures. In this study, artificial alveolar, lysosomal, and interstitial fluids were used to mimic physiological environments for identifying material property aspects for hydrocarbon (Ag-HC) and polysaccharide (Ag-PS) coated silver NM. As inhalation is a common route of exposure, an alveolar macrophage cell model with deposition dosages representing approximately 2.5 months and 10 years of occupational exposure (0.5 and 25 ng/mL, respectively) were employed. Following dispersion in the artificial fluids, the Ag-HC and Ag-PS NPs demonstrated significant alterations to morphology, aggregation patterns, and particle reactivity. However, the Ag-PS also demonstrated a loss of particle coating, elicited an induced cytotoxicity, increased phagocytosis, and inflammation not associated with the original Ag-PS. This study demonstrated that in a physiological system NMs undergo considerable modulation introducing a scenario where NMs that were initially not to have frank toxicity do change over time with internal bioconditions. The dynamics of solid phase chemical material after exposure dosing remains a critical research area for defining the full bioeffects impact of nanomaterials with limited aqueous solubility.

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