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首页> 美国政府科技报告 >Immunization with Porphyromonas Gingivalis Cysteine Protease: Effects onExperimental Gingivitis and Ligature-Induced Periodontitis in Macaca Fascicularis
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Immunization with Porphyromonas Gingivalis Cysteine Protease: Effects onExperimental Gingivitis and Ligature-Induced Periodontitis in Macaca Fascicularis

机译：牙龈卟啉单胞菌半胱氨酸蛋白酶免疫对猕猴实验性牙龈炎和结扎诱导的牙周炎的影响

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Targeting specific bacterial virulence factors such as proteases for immunizationmay hold the key to limiting or preventing loss of attachment and alveolar bone in periodontal disease. This study was undertaken to examine the clinical, microbiological and immunological responses following active immunization with a purified 120 kDa Porphyromonas gingivitis cysteine protease (porphypain-2) in the nonhuman primate (Nhp) Macaca fascicularis (cynomolgus monkey). 4 Nhp were immunized with 100ug of porphypain-2 antigen at baseline, 2 and 4 weeks. A 'non-immunized' control group of 4 Nhp received placebo injections. The animals were subjected to a 4 week experimental gingivitis phase initiated by soft diet, followed by a 13 week ligature-induced periodontitis phase. Mandibular left 'test' teeth (3-5, 3-6, 3-7) in each animal received silk ligatures to initiate periodontitis, with mandibular right teeth (4-5, 4-6, 4-7) in each animal serving as a non-ligated intra-animal control. Clinical, radiographic, microbiologic and immunologic data were gathered and analyzed using the student t-test and nonparametric rank analyses. An ELISA demonstrated that immunization elicited an elevated and specific IgG response to both whole cell P. gingivalis (36-fold) and

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