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Colonic healing: the effect of irradiation and chemotherapy - an experimental study, resembling adjuvant therapy for colorectal carcinoma

机译：结肠愈合：辐射和化疗的影响 - 一项实验研究，类似于结肠直肠癌的辅助治疗

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Adjuvant treatment of colon and rectal carcinoma is of major interest. Irradiation and chemotherapy are modalities used widely. The purpose of this study was to evaluate the effect of preoperative irradiation and postoperative intraperitoneal 5-fluorouracil treatment on colonic healing. In rats preoperative irradiation of the lower abdominal region by 10 + 10 Gy four days apart caused inflammatory reaction in the colon as evaluated by histology and determination of myeloperoxidase activity. The inflammatory reaction reached its peek within a week of the second irradiation. When standard used colonic resections and anastomes were performed within the irradiate part of the colon the anastomotic healing was not affected during the first week after operation as judged by complications and breaking strength. A lower breaking strength and an increase in myeloperoxidase activity two months after operation may indicate late changes within the intestinal wall. Intraperitoneal 5-fluorouracil in rat given immediately after colonic resection and repeated as daily injections caused a weight loss and marked reduction in breaking strength of the anastomosis as well as in the abdominal skin wound. A reduction in 5-fluorouracil concentration did not alter the negative wound healing effect of the chemotherapy. In a group of rats subjected to nutritional depletion, mimicking the weight curve of 5-fluorouracil treated animals, anastomotic breaking strength was not compromised to the same extent as when 5-fluorouracil was given. This indicated a direct toxic effect rather than an effect of reduced food intake caused by 5-FU treatment. Collagen synthesis and the formation of new tissue in the wound gap was reduced in 5-fluorouracil treated animals compared to controls as judged by in vivo incorporation of (sup 3)H-proline in the anastomotic segment and determination of anastomotic breaking strength after removal of sutures. 108 refs. (Atomindex citation 25:014451)

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作者
Weiber, S.;
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年度 1993
页码 1-48
总页数 48
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Chemotherapy; Carcinomas; Experimental Data; Fluorouracils; Healing; Irradiation; Large Intestine; Rats; Surgery; Time Dependence; Wounds; Tables(data);

机译：化学疗法;癌;实验数据;氟尿嘧啶;愈合;辐射;大肠;大鼠;手术;时间依赖性;伤口;表（数据）;

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1. Impact of adjuvant systemic chemotherapy on wound healing and cosmetic outcome in 224 women treated with accelerated partial breast irradiation using interstitial brachytherapy [J] . Budrukkar Ashwini, Pandit Prakash, Wadasadawala Tabassum, Brachytherapy . 2017,第5期

机译：辅助全身化疗对224名妇女伤口愈合和化妆品结果的影响，采用间质近距离放射治疗治疗加速部分乳房辐射
2. Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) – a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)– the AIO/ CALGP/ ACO- GAIN-trial – [J] . Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, BMC Cancer . 2020,第1期

机译：Neoadjuvant化疗用吉西滨加顺铂，随后是自由基肝切除与直接自由基肝切除单独有或没有辅助化疗，偶然检测到胆囊癌后简单的胆囊切除术或在BTC（ICC / ECC）的激进切除前 - A阶段III研究德国偶然胆囊癌癌平台（GR） - AIO / CALGP / ACO-增益试验 -
3. Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era [J] . Ludmir Ethan B., Arya Ritu, Wu Yuan, Annals of surgical oncology . 2016,第3期

机译：辅助放疗在现代化疗时代在局部晚期结肠癌中的作用
4. Experimental studies of combination of PDT and tumor chemotherapy or 60Co irradiation [C] . Janina Didziapetriene, Lithuanian Oncology Ctr., Vilnius, Photodynamic Therapy of Cancer II . 1995

机译：PDT与肿瘤化疗或60Co照射联合应用的实验研究
5. Benzyl Isothiocyanate as an Adjuvant Chemotherapy Option for Head and Neck Squamous Cell Carcinoma. [D] . Wolf, Mary Allison. 2014

机译：异硫氰酸苄酯作为头颈鳞状细胞癌的辅助化疗选择。
6. Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) – a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)– the AIO/ CALGP/ ACO- GAIN-trial – [O] . Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, 2020

机译：在单纯胆囊切除术后或在BTC根治性切除前偶然发现的胆囊癌中吉西他滨联合顺铂的新辅助化疗联合根治性肝切除与单独进行或不进行辅助性化疗的立即根治性肝切除–Ⅲ期研究德国偶然胆囊癌平台注册处（AIO / CALGP / ACO-GAIN-trial-
7. Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) – a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)– the AIO/ CALGP/ ACO- GAIN-trial – [O] . Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, 2020

机译：Neoadjuvant化疗用吉西滨加顺铂，随后是自由基肝切除与直接自由基肝切除单独有或没有辅助化疗，偶然检测到胆囊癌后简单的胆囊切除术或在BTC（ICC / ECC）的激进切除前 - A阶段III研究德国偶然胆囊癌癌平台（GR） - AIO / CALGP / ACO-增益试验 -

Colonic healing: the effect of irradiation and chemotherapy - an experimental study, resembling adjuvant therapy for colorectal carcinoma

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