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Non-invasive evaluation of the cardiac autonomic nervous system by PET. Progress report, September 1991--September 1992

机译：pET对心脏自主神经系统的无创评估。进展报告，1991年9月至1992年9月

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The proposed research addresses the development, validation and application of cardiac PET imaging techniques to characterize the autonomic nervous system of the heart. PET technology has significantly matured over the last two decades. Instrument design, image processing and production of radiochemical compounds have formed an integrative approach to provide a powerful and novel imaging modality for the quantitative in vivo evaluation of the autonomic nervous system of the heart. Animal studies using novel tracers for the sympathetic and parasympathetic nerve terminals will be employed to characterize the functional integrity of nerve terminals. This work will be complemented by the development of agents which bind to postsynaptic receptor sites. The combined evaluation of presynaptic and postsynaptic neuronal function will allow a unique characterization of neuronal function. Initial development in animal studies will be followed by feasibility studies in humans. These studies are designed to test sophisticated imaging protocols in the human heart and validate the scintigraphic findings with independent markers of autonomic innervation. Subsequent clinical application in various cardiac diseases is expected to provide new insights into the neuropathophysiology of the heart.

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年度 1992
页码 1-12
总页数 12
原文格式 PDF
正文语种 eng
中图分类工业技术;
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EDB/550601; EDB/400703;

机译：EDB / 550601; EDB / 400703;

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7. Non-invasive evaluation of the cardiac autonomic nervous system by PET. Progress report [O] . 1992

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8. Non-invasive evaluation of the cardiac autonomic nervous system by PET. Progress report, September 1991--September 1992 [R] . 1992

机译：pET对心脏自主神经系统的无创评估。进展报告，1991年9月至1992年9月

Non-invasive evaluation of the cardiac autonomic nervous system by PET. Progress report, September 1991--September 1992

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