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首页> 美国政府科技报告 >Analysis of HLA-DP Association with Beryllium Disease Suspectibility in Pooled Exposed Populations. Final Report
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Analysis of HLA-DP Association with Beryllium Disease Suspectibility in Pooled Exposed Populations. Final Report

机译：HLa-Dp与汇集暴露人群中铍病可疑性的关联分析。总结报告

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摘要

Berylliosis or Chronic Beryllium Disease is a chronic granulomatous disorder primarily involving the lung associated with the exposition to low doses of Beryllium (Be) in the workplace. Berylliosis risk has been associated with the presence of a glutamate at position 69 of the HLA-DP beta chain (HLA-DPbetaGlu69) that is expressed in about 97% of disease cases and in 27% of the unaffected Be-exposed controls. Since this first observation of an immunogenetic association between berylliosis and HLA-DPbetaGlu69 a number of studies have confirmed the role of this marker as the primary gene of susceptibility of berylliosis. Moreover, a structure/function interaction between HLA-DP molecules carrying Glu69 and beryllium in driving and developing the immune response against beryllium itself has been observed as: (1) Be-specific T-cells clones obtained from berylliosis patients recognise beryllium as antigen only when presented in the context of the HLA-DPaGlu69 molecules but not in the context of HLA-DP allelic variants carrying Lys69, and (2) beryllium presents an affinity for the HLA-DP2, carrying the berylliosis marker of susceptibility HLA-DPGlu69, from 40 to 100 times higher that the HLA-DP molecule carrying Lys69.

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