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首页> 美国政府科技报告 >Sum Frequency Generation Vibrational Spectroscopy Studies on Model Peptide Adsorption at the Hydrophobic Solid-Water and Hydrophilic Solid-Water Interfaces
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Sum Frequency Generation Vibrational Spectroscopy Studies on Model Peptide Adsorption at the Hydrophobic Solid-Water and Hydrophilic Solid-Water Interfaces

机译：和谐频率生成振动光谱研究模型肽在疏水固 - 水和亲水固 - 水界面上的吸附

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The molecular understanding of protein adsorption on biopolymer surfaces provides the opportunity to develop biocompatible implant systems or prevent unfavorable protein adsorption from the blood onto medical devices, which alters their biological and immunological responses. Because of this, both the biomedical and surface science communities have taken an interest in understanding protein adsorption. Although protein adsorption has been the focus of many studies, details on the molecular structure of adsorbed proteins remains poorly understood. This is primarily due to the lack of a surface-specific technique that provides information on molecular structure at surfaces. Recently, the surface-specific technique of visible-infrared sum frequency generation (SFG) vibrational spectroscopy has been developed. This vibrational spectroscopy provides a molecular level understanding of adsorbate orientation and ordering at any interface accessible by light. Unfortunately, adsorbed proteins are difficult molecules to study with vibrational spectroscopy on a molecular level due to their size and structural complexity. Therefore, we have turned to the study of amino acids and small peptides as model systems.

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