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Experimental Study in the Rat of the Effect of Radon on the Normal and Dust-Treated Lung

机译：大鼠氡对正常和尘埃治疗肺癌影响的实验研究

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Studies in rats showed that radon, when inhaled in amounts in the range of 1 x 10 exp -6 Ci/l, did not have an early toxic action on pulmonary tissue. After an exposure to radon of 150 hours, distributed over a period of six months, the integrity of the parenchyma was completely intact. Delayed action of radon and its daughters was not studied. When radon was given with silica the process of nodal transport of the particles appeared to increase. This acceleration, which was visible histologically, was insufficient to include a change in weight of the particles retained in the lung, as measured chemically. An increase in inflammation of the pulmonary alveoli was noted in the animals subjected to radon and silica particles together. The fibrous lesions obtained in the presence of radon were different from the lesions caused by silica alone. Along with typical nodular lesions there were rather diffuse and scattered fibrous lesions, thickening of the septa, and infiltration of the perivascular and peribronchial sheaths. Also, chemical analysis of the collagen showed that there was less formation of collagen when the radon was combined with the silica. (ERA citation 03:036096)

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