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美国政府科技报告
>INVESTIGATIONS ON BONE MARROW TRANSPLANTATION IN IRRADIATED ANIMALS AND THE PRODUCTION OF SPECIFIC PATHOGEN FREE ANIMALS AND THEIR APPLICATION IN RADIOBIOLOGY Report covering the period 1.12.1962 - 31.12.1965
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INVESTIGATIONS ON BONE MARROW TRANSPLANTATION IN IRRADIATED ANIMALS AND THE PRODUCTION OF SPECIFIC PATHOGEN FREE ANIMALS AND THEIR APPLICATION IN RADIOBIOLOGY Report covering the period 1.12.1962 - 31.12.1965
The program on Lone marrow transplantation has consisted of fundamental studies which were performed with mice and rats, as well as preclinical experiments with monkeys.nAmong the most notable results are the successful homologous tone marrow transplantation in irradiated rats, which is partly to he ascribed to the use of specific pathogen free animals:the successful suppression of the acute secondary disease in monkeys following transplantation of homologous marrow;the development of an effective method of preservation of monkey bone marrow at low temperatures;the identification of leukocyte antigen groups probably representing tissue transplantation antigens in Rhesus monkeys;the Introduction or a new technique for the identification of antibody forming cells in vitro and the interpretation of the post-thymectomy wasting syndrome as a form of autoimmune disease.nThe project of specific pathogen free animals has progressed significantly during the past three years. Specific pathogen free rats have become a standard object of radiation studies.
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