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首页> 美国政府科技报告 >Gordon Research Conferences, 2003, on Genetic Toxicology. Held at Queen's College, United Kingdom, August 10-15, 2003. Final Progress Report
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Gordon Research Conferences, 2003, on Genetic Toxicology. Held at Queen's College, United Kingdom, August 10-15, 2003. Final Progress Report

机译：戈登研究会议，2003年，关于遗传毒理学。 2003年8月10日至15日在英国女王学院举行。最后进展报告

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Genetic toxicology represents a study of the genetic damage that a cell can incur, the agents that induce such damage, the damage response mechanisms available to cells and organisms, and the potential consequences of such damage. Genotoxic agents are abundant in the environment and are also induced endogenously. The consequences of such damage can include carcinogenesis and teratogenesis. An understanding of genetic toxicology is essential to carry out risk evaluations of the impact of genotoxic agents and to assess how individual genetic differences influence the response to genotoxic damage. In recent years, the importance of maintaining genomic stability has become increasingly recognized, in part by the realization that failure of the damage response mechanisms underlies many, if not all, cancer incidence. The Genetic Toxicology Gordon Research Conference is biannual with an evolving change in the emphasis of the meetings. From evaluating the nature of genotoxic chemicals, which lay at the centre of the early conferences, the emphasis has moved to understanding how cells and organisms respond to the different forms of genotoxic damage incurred. By understanding these mechanisms, the risk to humans can be more rationally assessed and evaluated. More recently, the format of the meetings have aimed to facilitate input from the range of disciplines that can now provide insight into the field. This evolution in emphasis has been continued in the format of the proposed 2003 meeting. In the last Genetic Toxicology Gordon Conference (2001), the aim was to integrate studies on genetic toxicology at the structural, molecular and cellular level with those involving mice and humans (2 micron to Man). In the 2003 conference, we aim to integrate the approaches from 2 micron to man together with approaches where our basic knowledge has been exploited in an applied context (2 micron to Man to manipulation).

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