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首页> 美国政府科技报告 >Miniaturized Analytical Platforms from Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures
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Miniaturized Analytical Platforms from Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

机译：纳米粒子组件的微型分析平台：这些新型架构的构造，特性和高吞吐量使用研究

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Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.

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