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首页> 美国政府科技报告 >Strategic Environment Research and Development Program (SERDP). Using Mode of Action to Assess Health Risks from Mixtures of Chemical/Physical Agents. Final Report
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Strategic Environment Research and Development Program (SERDP). Using Mode of Action to Assess Health Risks from Mixtures of Chemical/Physical Agents. Final Report

机译：战略环境研究与发展计划（sERDp）。运用行动模式评估化学/物理因素混合物的健康风险。最终报告

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摘要

Mixtures of carcinogenic solvents are found in ground water and soils at hazardous waste sites. While there is frequently data available for interactions between chemicals to judge risks from short-term exposures, data that describe how interactions influence the development of cancer are rare. This is largely because of the high cost associated with conducting complex interaction studies over the lifetime of experimental animals. The interactions between genotoxic and non-genotoxic carcinogens have long been recognized as having the potential of being synergistic as demonstrated in initiation/promotion studies. However, there are few systematic studies of interactions between chemicals considered to have non-genotoxic modes of action. The specific case addressed in this study is the co-occurrence of chlorinated solvents at DOD and DOE facilities. The most common of these are trichloroethylene (TCE), tetrachloroethylene (PERC) and carbon tetrachloride (CT).

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