• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >In-vivo Diagnosis of Chemically Induced Melanoma in an Animal Model Using UV-Visible and NIR Elastic Scattering Spectroscopy: Preliminary Testing
【24h】

In-vivo Diagnosis of Chemically Induced Melanoma in an Animal Model Using UV-Visible and NIR Elastic Scattering Spectroscopy: Preliminary Testing

机译：使用紫外 - 可见光和近红外弹性散射光谱法在动物模型中对化学诱导的黑素瘤进行体内诊断：初步测试

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Elastic light scattering spectroscopy (ESS) has the potential to provide spectrathat contain both morphological and chromophore information from tissue. We report on a preliminary study of this technique, with the hope of developing a method for diagnosis of highly-pigmented skin lesions, commonly associated with skin cancer. Four opossums were treated with dimethylbenz(a)anthracene to induce both malignant melanoma and benign pigmented lesions. Skin lesions were examined in vivo using both UV-visible and near infrared (NIR) ESS, with wavelength ranges of 330-900 nm and 900-1700 nm, respectively. Both portable systems used identical fiber-optic probe geometry throughout all of the measurements. The core diameters for illuminating and collecting fibers were 400 and 200 (micro)m, respectively, with center-to-center separation of 350 (micro)m. The probe was placed in optical contact with the tissue under investigation. Biopsies from lesions were analyzed by two standard histopathological procedures. Taking into account only the biopsied lesions, UV-visible ESS showed distinct spectral correlation for 11/13 lesions. The NIR-ESS correlated well with 12/13 lesions correctly. The results of these experiments showed that UV-visible and NIR-ESS have the potential to classify benign and malignant skin lesions, with encouraging agreement to that provided by standard histopathological examination. These initial results show potential for ESS based diagnosis of pigmented skin lesions, but further trials are required in order to substantiate the technique.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号