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Role of Low Frequency Collective Modes in Biological Function: Ligand Binding and Cooperativity in Calcium-Binding Proteins

机译：低频集体模式在生物功能中的作用：钙结合蛋白的配体结合和协同作用

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The focus of this proposal was to study the low-frequency collective modes in proteins that have been widely discussed as potential means for direct control of biochemical processes. While it has been shown that protein dynamics are required for protein function, there is scant experimental data to establish a clear link between the specific details of the dynamics and control of a specific function. We used a combination of isotope labeling with Nuclear Magnetic Resonance (NMR) relaxation to probe the dynamic fluctuations within an individual domain of the calcium-binding protein calmodulin. Cellular functions are regulated via the actions of a number of messengers of which the divalent calcium ion is perhaps the simplest.

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Trewhella, J.;
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年度 2001
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Ligands ; Proteins ; Biological effects ; Calcium ; Biochemistry ; Cell structures ; Molecular properties ; Dynamics ; Spectroscopy ; Nuclear magnetic resonance;

机译：配体;蛋白质;生物效应;钙;生物化学;细胞结构;分子特性;动力学;光谱学;核磁共振;

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专利

1. Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells [J] . Ping Han, Jiazhi Liao, Dongxiao Li, Biology Open . 2017,第1期

机译：抑制组氨酸丰富的钙结合蛋白（HRC）通过抑制肝星状细胞的激活抑制肝纤维化抑制组氨酸丰富的组氨酸钙结合蛋白（HRC）通过抑制肝星状细胞的抑制肝纤维化丰富的钙结合蛋白（HRC）通过抑制肝星状细胞的活化来抑制肝纤维化
2. From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site [J] . Jollegrave, s Pierre, Schoentgen Franccedil, FEBS Letters . 1995,第1期

机译：从结构到功能：新的广泛蛋白家族结合疏水配体并显示核苷酸结合位点的可能生物学作用
3. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. [J] . Donato R Biochimica et biophysica acta: international journal of biochemistry and biophysics . 1999,第3期

机译：S100蛋白（EF手型钙结合蛋白）的功能作用。
4. CALCULATION OF PROTEIN-LIGAND BINDING FREE ENERGYUSING SMOOTH REACTION PATH GENERATION (SRPG) METHOD;A COMPARISON OF THE EXPLICIT WATER MODEL, GB/SA MODELAND DOCKING SCORE FUNCTION [C] . DAISUKE MITOMO, YOSHIFUMI FUKUNISHI, JUNICHI HIGO, International Conference on Genome Informatics . 2009

机译：蛋白质 - 配体结合的可自由诱导光滑反应径生成（SRPG）方法的计算;明确水模型的比较，GB / SA Model和对接得分函数
5. CHARACTERIZATION AND FUNCTION OF CALCIUM-BINDING PROTEINS: CALMODULIN, CALMODULIN-DEPENDENT NAD KINASE, AND PROKARYOTIC CALCIUM-BINDING PROTEINS [D] . HARMON, ALICE CLAIRE GARDNER 1985

机译：钙结合蛋白的表征和功能：钙调蛋白，钙依赖性蛋白依赖性NAD激酶和原核钙结合蛋白
6. Functional roles and efficiencies of the thioredoxin boxes of calcium-binding proteins 1 and 2 in protein folding. [O] . B Kramer, D M Ferrari, P Klappa, 2001

机译：钙结合蛋白1和2的硫氧还蛋白盒在蛋白质折叠中的功能作用和效率。
7. The role of low frequency collective modes in biological function: Ligand binding and cooperativity in calcium-binding proteins [O] . Trewhella, J. 2000

机译：低频集体模式在生物功能中的作用：配体结合和钙结合蛋白的协同作用

Role of Low Frequency Collective Modes in Biological Function: Ligand Binding and Cooperativity in Calcium-Binding Proteins

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