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首页> 美国政府科技报告 >Kinetics of Beta-((14)C) Carotene in a Human Subject Using Acclerator Mass Spectrometry
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Kinetics of Beta-((14)C) Carotene in a Human Subject Using Acclerator Mass Spectrometry

机译：利用acclerator质谱技术研究人体β - （（14）C）胡萝卜素的动力学

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Beta-carotene is a tetraterpenoid distributed widely throughout the plant kingdom. It is a member of a group of pigments referred to as carotenoids that have the distinction of serving as metabolic precursors to vitamin A in humans and many animals. We used Accelerator Mass Spectrometry (AMS) to determine the metabolic behavior a physiologic oral dose of Beta-((14)C) carotene (200 nanoCuries; 0.57) in a healthy human subject. Serial blood specimens were collected for 210-d and complete urine and feces were collected for 17 and 10-d, respectively. Balance data indicated that the dose was 42% bioavailable. The absorbed Beta-carotene was lost slowly via urine in accord with the slow body turnover of 13-carotene and vitamin A. HPLC fractionation of plasma taken at early time points (0-24-h) showed the label was distributed between 13-carotene and retinyl esters (vitamin A) derived from intestinal metabolism.

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