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首页> 美国政府科技报告 >Initial Submission: Letter from (Confidential) to USEPA Reporting Results of Mutagenicity and Clastogenicity Studies of (Confidential), Triazolinone, dated 02/09/1999. (Sanitized)
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Initial Submission: Letter from (Confidential) to USEPA Reporting Results of Mutagenicity and Clastogenicity Studies of (Confidential), Triazolinone, dated 02/09/1999. (Sanitized)

机译：初始提交：（机密）致美国环保局1999年9月2日提交的（机密）三唑啉酮致突变性和致裂性研究结果的函件。 （的sanitized）

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In two independent trials, the test material produced a dose-dependent increase in the number of revertants in Salmonella typhimurium, strain TA100 only. The assay produced positive results in both the presence and absence of S9,at concentrations of 200 pg/plate and above in the absence of S9, and at 1000 pg/plate and above in the presence of S9. The range of exposure concentrations was 8-5000 pg/plate for the first trial and 312.5-5000 pg/plate in the second trial. The assay was negative in both trials using strains TA 98, TA 1535, TA 1537, and TA 102. In two independent trials, the test material was positive for induction of chromosome aberrations in human lymphocytes. In the first trial, when cells were exposed for 3 hours with S9 activation at concentrations of 60.53 - 514.5 ug/mL, a statistically significant increase in the percent of cells with structural aberrations was produced at the highest concentration. No increase was observed when cells were exposed to 176.5 - 360.1 ug/mL in the absence of S9. In the second trial, when cells were exposed for 20 hours without S9 activation at concentrations of 42.37 - 123.5 ug/mL, a dose-dependent, statistically significant increase in the percent of cells with structural aberrations was produced in cells exposed to 86.47 pg/mL and above.

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