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首页> 美国政府科技报告 >Differential effects of atomic bomb irradiation in inducing major leukemia types. Analyses of open-city cases including the Life Span Study cohort based upon updated diagnostic systems and the dosimetry system 1986(DS86)
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Differential effects of atomic bomb irradiation in inducing major leukemia types. Analyses of open-city cases including the Life Span Study cohort based upon updated diagnostic systems and the dosimetry system 1986(DS86)

机译：原子弹辐射诱导主要白血病类型的不同影响。开放城市案例分析，包括基于更新的诊断系统和剂量测定系统1986（Ds86）的寿命研究队列

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In this report we utilize data from the additional 517 cases from the leukemia registry together with the Life Span Study (LSS) cohort data to study the effects of atomic bomb irradiation on major leukemia types. The French-American-British classification and other improved diagnostic methods were used to reclassify cases into 21 categories, including new disease entities such as adult T-cell leukemia (ATL). These categories were then grouped into four major types for analysis: (1) acute lymphocytic leukemia (ALL), (2) acute myeloid leukemia (AML) including myelodysplastic syndromes (MDS), (3) chronic myeloid leukemia (CML), and (4) OTHER types including ATL. Analyses of radiation effects were based on the updated Dosimetry System 1986(DS86). Incidence rates of all four leukemia types increased with increasing exposure level. The effects of radiation were significantly greater on the incidence of ALL and CML than on that of AML and OTHER. In the two lowest dose categories (1-49 and 50-499 mGy), estimated incidence either remained constant or increased slightly as the population of survivors aged. In the two highest dose categories (500-1,499 and (>=) 1,500 mGy). Among unexposed persons, the estimated risk of CML in Nagasaki relative to Hiroshima was significantly less than that of AML, whereas that of OTHER types was significantly greater. The time to onset of ALL, AML, and CML declined with increasing dose. The rate of decline, however, was greater for ALL and CML than for AML. The resulting differences at high doses reflect shorter incubation times for atomic-bomb-induced ALL and CML than for AML. (J.P.N.). (ERA citation 19:013311)

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