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Viral evolution under the pressure of an adaptive immune system - optimal mutation rates for viral escape

机译：在适应性免疫系统的压力下的病毒进化 - 病毒逃逸的最佳突变率

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摘要

Based on a recent model of evolving viruses competing with an adapting immune system, we study the conditions under which a viral quasispecies can maximize its growth rate.

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作者
Kamp, C.; Wike, C. O.; Adami, C.; Bornholdt, S.;
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年度 2002
页码 1-14
总页数 14
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
MUTATIONS; VIRUSES; viral evolution immune system HIV;

机译：突变;病毒;病毒进化免疫系统HIV;

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专利

1. Synthesizing within-host and population-level selective pressures on viral populations: the impact of adaptive immunity on viral immune escape [J] . Igor Volkov, Kim M. Pepin, James O. Lloyd-Smith Journal of the Royal Society Interface . 2010,第50期

机译：综合宿主和人群水平的病毒种群压力：适应性免疫对病毒免疫逃逸的影响
2. Immune escape mutations detected within HIV-1 epitopes associated with viral control during treatment interruption. [J] . Schweighardt B, Wrin T, Meiklejohn D JAIDS: Journal of acquired immune deficiency syndromes . 2010,第1期

机译：在治疗中断期间，在与病毒控制有关的HIV-1表位中检测到了免疫逃逸突变。
3. Symptomatic Hepatitis B Virus (HBV) Reactivation despite Reduced Viral Fitness Is Associated with HBV Test and Immune Escape Mutations in an HIV-Coinfected Patient. [J] . Henke-Gendo C, Amini-Bavil-Olyaee S, Challapalli D, The Journal of Infectious Diseases . 2008,第11期

机译：尽管病毒适应性降低，但症状性乙型肝炎病毒（HBV）的重新激活与HIV合并感染患者的HBV测试和免疫逃逸突变相关。
4. Co-evolving mutations in hepatitis C virus in the context of immune escape against neutralising antibody responses - A bioinformatic workflow for the analysis of co-evolving mutations in viral genomes [C] . Preston Leung, Rowena Bull, Andrew Lloyd, IEEE International Workshop on Artificial Immune Systems . 2015

机译：在针对中和抗体反应的免疫逃逸情况下丙型肝炎病毒的共同进化突变-分析病毒基因组共同进化突变的生物信息学工作流程
5. Viral escape of MHC-dependent immune recognition in a mouse/influenza model. [D] . Slev, Patricia Raluca. 1997

机译：小鼠/流感模型中MHC依赖性免疫识别的病毒逃逸。
6. Synthesizing within-host and population-level selective pressures on viral populations: the impact of adaptive immunity on viral immune escape [O] . Igor Volkov, Kim M. Pepin, James O. Lloyd-Smith, 2010

机译：综合宿主和人群水平对病毒种群的选择压力：适应性免疫对病毒免疫逃逸的影响
7. Viral evolution under the pressure of an adaptive immune system - optimal mutation rates for viral escape [O] . Kamp, Christel, Wilke, Claus O., Adami, Christoph, 2002

机译：适应性免疫系统压力下的病毒进化 - 病毒逃逸的最佳突变率

Viral evolution under the pressure of an adaptive immune system - optimal mutation rates for viral escape

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