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Mechanisms of Graft-vs.-Leukemia against a Novel Murine Model of Chronic Myelogenous Leukemia

机译：移植物抗白血病对新型慢性粒细胞白血病小鼠模型的作用机制

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Our objective is to understand the immunobiology underlying the differential sensitivity of chronic phase and blast crisis CML. Our data thus far support the hypothesis that GVL against mCP-CML can be mediated by redundant processes and that impairment of an individual pathway is insufficient to prevent GVL. We hypothesize that GVL against BC-CML is less forgiving than that against CP-CML, and that multiple effector pathways must act in concert for effective GVL. In the last year we have: (1) determined that cognate interactions are required for 0D4 and 0D8-mediated GVL; (2) determined that host antigen presenting cells are required for both 0D4 and 0D8-mediated GVL; (3) determined that killing by either FasL or TNF-o is not required for 0D4 or 0D8-mediated GVL; (4) created B7H14- mBC-CML; (5) determined that B7Hi expressed on mBC-CML does not impede 0D8-mediated GVL; (6) created TGF-p4- mBC- CML; and (7) determined that effector memory 0D4 cells can mediate GVL against mBC-CML.

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Shlomchik, W. D.;
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年度 2006
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Neoplasms; Leukemia; Sensitivity; Hypotheses; Immunology; Differential cross sections; Redundancy; Antigens; Skin grafts;

机译：肿瘤;白血病;敏感性;假设;免疫学;微分截面;冗余;抗原;皮肤移植;

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1. Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant [J] . Catherine Matte-Martone, Srividhya Venkatesan, Hung Sheng Tan, The journal of immunology . 2011,第4期

机译：对抗小鼠疾风爆发性慢性粒细胞性白血病（BC-CML）和慢性阶段性慢性粒细胞性白血病（CP-CML）的移植物抗白血病（GVL）：T细胞杀伤的共享机制，但程序性死亡配体导致CP-CML和不耐BC-CML GVL
2. Graft-versus-Leukemia (GVL) against Mouse Blast-Crisis Chronic Myelogenous Leukemia (BC-CML) and Chronic-Phase Chronic Myelogenous Leukemia (CP-CML): Shared Mechanisms of T Cell Killing, but Programmed Death Ligands Render CP-CML and Not BC-CML GVL Resistant. [J] . Matte Martone C, Venkatesan S, Tan HS, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第4期

机译：对抗小鼠疾风爆发性慢性粒细胞性白血病（BC-CML）和慢性阶段性慢性粒细胞性白血病（CP-CML）的移植物抗白血病（GVL）：T细胞杀伤的共享机制，但程序性死亡配体导致CP-CML和不耐BC-CML GVL。
3. Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models. [J] . Ren R Leukemia and lymphoma . 2002,第8期

机译：使用鼠模型剖析慢性粒细胞性白血病的分子机制。
4. Global Sensitivity Analysis for a Chronic Myelogenous Leukemia Model [C] . Gabriel Dimitriu International Conference on Numerical Methods and Applications . 2019

机译：慢性髓性白血病模型的全局敏感性分析
5. Dissecting molecular mechanisms of leukemogenesis with a mouse chronic myelogenous leukemia model. [D] . Gross, Alec William. 2002

机译：用小鼠慢性骨髓性白血病模型剖析白血病发生的分子机制。
6. Blast crisis in a murine model of chronic myelogenous leukemia. [O] . G Q Daley, R A Van Etten, D Baltimore 1991

机译：慢性粒细胞白血病小鼠模型中的高炉危机。
7. The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model [O] . Ruibao Ren 2002

机译：慢性髓性白血病的分子机制及其治疗意义：小鼠模型的研究

Mechanisms of Graft-vs.-Leukemia against a Novel Murine Model of Chronic Myelogenous Leukemia

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