• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Electron Spin Resonance Studies on the Detectability of Radiation Damage and Radiosensitization of Neoplastic Cells. Coordinated Programme on Improvement of Radiotherapy of Cancer Using Modifiers of Radiosensitivity of Cells. Fina
【24h】

Electron Spin Resonance Studies on the Detectability of Radiation Damage and Radiosensitization of Neoplastic Cells. Coordinated Programme on Improvement of Radiotherapy of Cancer Using Modifiers of Radiosensitivity of Cells. Fina

机译：电子自旋共振研究辐射损伤的可检测性和肿瘤细胞的放射增敏作用。利用细胞放射敏感性改良剂改善癌症放射治疗的协调计划。菲娜

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The comparison of direct and indirect ESR methods applicable for the examination of radiation damage to melanoma cells leads to the conclusion that only the indirect ones appear to be useful for its detection. The new results of animal experiments and clinical trials carried out according to the rules of radio-chelation therapy are briefly discussed. Selective incorporation of exp 35 S-labelled compounds by pigmented hamster melanoma cells was found to be followed by a depression of their proliferative activity in vitro and in situ, which may suggest the possible therapeutic value of endo-irradiation. The ESR measurements performed with the use of newly elaborated indirect methods revealed that pigmented and non-pigmented cells consume oxygen at significantly different rates, which means that oxygen utilization may contribute to the overall level of radioresistance of melanoma cells. This assumption has been confirmed by comparing the radiosensitivity of melanotic and amelanotic cells to fast neutrons. Pigment-containing hamster melanoma cells which are twice as resistant to low LET radiation as their non-pigmented counterparts, proved to be equally susceptible to neutrons. The chance of improving the efficiency of radiotherapy of malignant melanomas does not appear unlikely in the light of new experimental data and clinical trials. (Atomindex citation 14:728292)

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号