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首页> 美国政府科技报告 >Therapy of Soman Poisoning in the Rat by Direct Effects of Oximes Unrelated toCholinesterase-Reactivation (Behandeling van Somanvergiftiging op Basis van Directe Effecten van Oximen, Niet Gerelateerd aan Reactivatie van het Cholinesterase)
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Therapy of Soman Poisoning in the Rat by Direct Effects of Oximes Unrelated toCholinesterase-Reactivation (Behandeling van Somanvergiftiging op Basis van Directe Effecten van Oximen, Niet Gerelateerd aan Reactivatie van het Cholinesterase)

机译：通过与缬氨酸酯酶重新激活无关的肟的直接作用治疗大鼠梭曼中毒（Behandeling van somanvergiftiging op Basis van Directe Effecten van Oximen，Niet Gerelateerd aan Reactivatie van het Cholinesterase）

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Isolated rat diaphragm preparations treated with soman or with the irreversible'pre-aged' cholinesterase (ChE) inhibitor V(sub 27), showed a considerable recovery of the neuromuscular transmission (NMT) during incubation with the bispyridinium oximes HI-6, HGG-12, P(sub 2)S and obidoxime. In the soman-treated preparations the NMT recovery was predominantly caused by reactivation of acetylcholinesterase (AChE) but in the V(sub 27) treated preparations it was caused by a direct (pharmacological) effect unrelated to enzyme reactivation. Atropinized rats were artificially ventilated after injection with 3xLD(sub 50) soman for 3 hours and then treated with HI-6, i.e. at a time when oxime reactivation of soman inhibited ChE is no longer possible. Still, these rats started to breathe spontaneously and 50% survived more than 24h, whereas all control animals (saline instead of HI-6) died within 10 min after artificial ventilation was terminated. It is concluded that in the case the NMT found was based on synaptic adaptation to the continued inhibition of ChE and that the survival of the animals was due to a combination of the synaptic adaptation and central direct effects of HI-6.

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