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首页> 美国政府科技报告 >N-Nitrosodiethylamine-Induced Hepatocarcinogenesis in Estuarine Sheepshead Minnow ('Cyprinodon variegatus'): Neoplasms and Related Lesions Compared with Mammalian Lesions
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N-Nitrosodiethylamine-Induced Hepatocarcinogenesis in Estuarine Sheepshead Minnow ('Cyprinodon variegatus'): Neoplasms and Related Lesions Compared with Mammalian Lesions

机译：N-Nitrosodiethylamine诱导河口绵羊minnow（'Cyprinodon variegatus'）的肝癌发生：肿瘤和相关病变与哺乳动物病变相比

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Groups of estuarine sheepshead minnows (Cyprinodon variegatus) were exposed to 50-60 mg/l N-nitrosodiethylamine (DENA) for five to six weeks. Exposure was stopped and the fish were then transferred to clean, flowing seawater. Induced liver lesions were studied in periodic samples of fish taken during the next 67 weeks of holding. Most of these lesions were compared to their counterpart lesions in the rat. Certain lesions such as hepatocellular carcinomas, cholangiolar carcinomas, spongiosis hepatis (SH), and cholangiofibrosis in the fish have apparent similar cellular origins and morphogenesis to those Lesions in rats, and perhaps in other mammals. SH in the sheepshead minnow apparently arises from perisinusoidal cells and may be a neoplasm of the cell type. The general similarity of response to DENA in sheepshead minnows and rats suggests that the fish has promise as an assay subject for identifying some hepatocarcinogens, and as a sentinel organism for detecting hepatocarcinogens in contaminated coastal waters.

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