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首页> 美国政府科技报告 >Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea
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Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea

机译：乙基亚硝基脲和甲基亚硝基脲对小鼠骨髓细胞体内姐妹染色单体交换诱导的动力学

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Administration of ethylnitrosourea (ENU) (20, 25, 40, 50, and 60 mg/kg body weight) or methylnitrosourea (MNU) (25, 40, 50, 60, 75, and 80 mg/kg body weight) to male CD-1 mice 2 hours after subcutaneous implantation of 5-bromo-2'-deoxyurdine (BrdUrd) pellet (55 mg) resulted in a dose-dependent increase in sister chromatid exchanges (SCE) in bone marrow cells. Treatment with ENU (50 mg/kg body weight) at several time points prior to BrdUrd implantation resulted in a biphasic curve of SCE induction indicating at least two events that result in SCEs. Treatment with ENU at the time of BrdUrd implantation and post-BrdUrd reflected a similar mechanism apparent in the preBrdUrd curve. Treatment with MNU (50 mg/kg body weight) pre- and post-BrdUrd resulted in a linear monophasic curve of SCE induction in both the pre- and post-BrdUrd time periods. The overall MNU time-course curve resembled an inverted V function indicating the mechanism of SCE induction for ENU and MNU are different.

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