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首页> 美国政府科技报告 >Examination of the Relationship between Induction of Hepatic Ornithine Decarboxylase and DNA Synthesis in Light Adapted Rats Treated with Dexamethasone or Phenobarbital (Constant Lighting: Tumor Promoters)
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Examination of the Relationship between Induction of Hepatic Ornithine Decarboxylase and DNA Synthesis in Light Adapted Rats Treated with Dexamethasone or Phenobarbital (Constant Lighting: Tumor Promoters)

机译：地塞米松或苯巴比妥治疗轻型大鼠肝脏鸟氨酸脱羧酶诱导与DNa合成的关系（恒定照明：肿瘤启动子）

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摘要

ODC induction appears casually related as DNA synethesis and both are associated with the process of tumor formation. The authors have investigated the effects of phenobarbital and dexamethasone on hepatic ODC activity and DNA synthesis over 24 hrs in rats adapted to constant lighting from birth to eliminate light-induced feeding behavior as a variable in these endpoints. Phenobarcital induced a triphasic (4 hrs, 10 hrs and 18 hrs) increase in ODC activity (2-3 fold above control), but progressively inhibited DNA synthesis to 50% of control values by 14 hrs. However, this was followed by a 2-fold increase over 0 time DNA synthesis by 20 hrs. In contrast, dexamethasone induced only a monophasic stimulation of ODC activity and a continued inhibition of DNA synthesis to 24 hrs.

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