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DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats

机译：7,12-二甲基苯（a）蒽及其非致癌2-氟类似物在雌性sprague-Dawley大鼠中形成DNa加合物

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The potent polycyclic aromatic hydrocarbon 7.2 dimethylbenz(a)anthracene (DMBA) bound to the DNA of numerous organs of the female outbred Sprague-Dawley rat after iv administration under a regimen known to produce a high yield of mammary adenocarcinomas. The maximum DNA binding levels observed following iv administration of 5 mg DMBA range from approximately 12 micromol hydrocarbon/mol deoxyribonucleic for the liver to approximately 5 micromol hydrocarbon/mol deoxyribonucleotide for the mammary gland, the target tissue.

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作者
Daniel, F. B. ; Joyce, N. J.;
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年度 1982
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Deoxyribonucleic acids; Females; Rats; Laboratory animals; Reprints;

机译：脱氧核糖核酸;雌性;大鼠;实验动物;重印;

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专利

1. Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz(a)anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells. [J] . El Bayoumy K, Das A, Boyiri T, Chemico-biological interactions . 2003,第2期

机译：1,4-亚苯基二（亚甲基）硒氰酸酯及其代谢物对大鼠体内7,12-二甲基苯并（a）蒽-DNA加合物形成和大鼠乳腺肿瘤细胞增殖的比较作用。
2. Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen 7,12-dimethylbenz(a)anthracene. [J] . Manjanatha MG, Lyn Cook LE, Culp SJ, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1996,第1a2期

机译：与致瘤剂量的乳腺致癌物7,12-二甲基苯并（蒽）蒽治疗的大鼠中淋巴细胞突变体频率与DNA加合物形成的关系。
3. Heating Garlic Inhibits Its Ability to Suppress 7,12-Dimethylbenz(a)anthracene-Induced DNA Adduct Formation in Rat Mammary Tissue [J] . Kun Song, John A. Milner5 The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 1999,第3期

机译：加热大蒜抑制其抑制大鼠乳腺组织中7,12-二甲基苯并（a）蒽诱导的DNA加合物形成的能力
4. 7,12-Dimethylbenz(a)anthracene induced breast cancer in Sprague Dawley rats proved by ultrasound imaging [C] . Mutmainnah Arif, Padlianah, Ika Yustisia International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research . 2019

机译：7,12-二甲基苄苯（A）蒽诱导的Sprague Dawley大鼠乳腺癌通过超声成像证明
5. The role of genotoxicity in 7,12-dimethylbenz[a]anthracene-induced splenic immunotoxicity [D] . Gao, Jun 2007

机译：遗传毒性在7,12-二甲基苯并[a]蒽诱导的脾脏免疫毒性中的作用
6. Enhancement and inhibition of the induction by 712-dimethylbenz(a)anthracene of mammary tumours in female Sprague-Dawley rats. [O] . D. N. Wheatley 1968

机译：增强和抑制712-二甲基苯并（a）蒽对雌性Sprague-Dawley大鼠乳腺肿瘤的诱导作用。
7. Enhancement and inhibition of the induction by 7,12-dimethylbenz(a)anthracene of mammary tumours in female Sprague-Dawley rats. [O] . Wheatley, D. N. 1968

机译：增强和抑制7,12-二甲基苯并（a）蒽对雌性Sprague-Dawley大鼠乳腺肿瘤的诱导作用。
8. 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid) [R] . Joyce, N. J. , Daniel, F. B. 1982

机译：7,12-二甲基苯（a）蒽 - 脱氧核糖核苷加合物'体内'形成：单羟甲基-DmBa（二甲基苯（a）蒽）代谢物与大鼠肝DNa（脱氧核糖核酸）形成和结合的证据

DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats

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