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Adriamycin Cardiotoxicity: A Comparison with Adriamycin, Aclacinomycin A (NSC 208734).

机译：阿霉素心脏毒性：与阿霉素，阿克拉霉素a（NsC 208734）的比较。

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摘要

Adriamycin analog NSC 208734was less cardiotoxic than its parent compound. This conclusion is based on histologic,hematologic,serum enzyme and electrocardiographic studies. The analog failed to produce significant rental toxicity, myeloid suppression or myocardial toxicity. Animals receiving NSC 208734had lengthened survival and did not lose weight as compared with animals treated with Adriamycin.

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will, j. a. splitter, g. a. ;
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年度 1979
页码 1-121
总页数 121
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
toxicology; antineoplastic agents; drugscomparison; toxicity; dosage; dose rate; bioassay; laboratory animals; experimental data; pathology; lethal dosage; rabbits; tables(data); hematology; clinical chemistry; electrocardiography; kidney; heart;

机译：毒理学;抗肿瘤药;药物比较;毒性;剂量;剂量率;生物测定;实验动物;实验数据;病理学;致死剂量;兔;表（数据）;血液学;临床化学;心电图;肾;心脏;

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专利

1. Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo [J] . F B Klugmann, G Decorti, L Candussio, British Journal of Cancer . 1986,第5期

机译：阿霉素诱导的组胺抑制剂的体外释放限制了体内阿霉素的心脏毒性
2. NSCA-l-a novel N-substituted coumalamide derivative-increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway [J] . Yanhua Fan, Jianyu Liu, Dan Liu, Environmental toxicology and pharmacology . 2017,第JANa期

机译：NSCA-1-一种新型N取代香豆酰胺衍生物可通过调节Akt /GSK-3β信号传导和p53依赖的凋亡途径来提高HepG2 / adriamycin细胞中阿霉素的敏感性
3. Multiagent Chemotherapy for Children with Advanced NeurohiastomaA Comparison of High-Dose Cyclophosphamide, vincristine and Adriamycin Therapy with James' Therapy plus Adriamycin [J] . YASUHIKO HIYOSHI, HIROMICHI YANO, TETSURO TANAKA, Kurume Medical Journal . 1984,第1期

机译：儿童晚期神经母细胞瘤的多药化学疗法大剂量环磷酰胺，长春新碱和阿霉素与詹姆斯疗法加阿霉素的比较
4. Ginkgo biloba extract (EGb761) protects against adriamycin-induced cardiotoxicity without interfereing with its antitumor activity [C] . Ding Qinxue, Liu Gengtao Proceedings of '97 international seminar on ginkgo . 1997

机译：银杏叶提取物（EGb761）可防止阿霉素引起的心脏毒性，而不会干扰其抗肿瘤活性
5. Molecular mechanisms of metallothionein protection from adriamycin cardiotoxicity. [D] . Merten, Kevyn Edward. 2005

机译：金属硫蛋白保护免受阿霉素心脏毒性的分子机制。
6. Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo. [O] . F. B. Klugmann, G. Decorti, L. Candussio, 1986

机译：阿霉素诱导的组胺的抑制剂在体外释放限制了阿霉素的体内心脏毒性。
7. Comparative studies on pharmacokinetics of adriamycin, THP-adriamycin, Epirubicin, Idarubicin, and aclacinomycin, the anthracycline anticancer antibiotics. [O] . HIROSHI FUJITA 1987

机译：亚霉素，甲状腺素，同质素，紫花霉素和海红霉素，蒽环菌抗生素的药代动力学比较研究。
8. Adriamycin Cardiotoxicity: A Comparison with 4'EPI-Adriamycin NSC No. 256942 [R] . Splitter, G. A. , Lalich, J. J. , de Dennis, S. R. K. , 1980

机译：阿霉素心脏毒性：与4'EpI-阿霉素NsC No.2566942的比较

Adriamycin Cardiotoxicity: A Comparison with Adriamycin, Aclacinomycin A (NSC 208734).

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