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首页> 美国政府科技报告 >Potential Health Hazards of Organic Pigments and Dyes Used in the Manufacture of Paints and Surface Coatings. Appendix I: Scientific Basis for the Proposed Regulation of Dyes Derived from the Chemical Substances Benzidine, 3,3'-Dimethylbenzidine, and 3,3'-Dimethoxybenzidine
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Potential Health Hazards of Organic Pigments and Dyes Used in the Manufacture of Paints and Surface Coatings. Appendix I: Scientific Basis for the Proposed Regulation of Dyes Derived from the Chemical Substances Benzidine, 3,3'-Dimethylbenzidine, and 3,3'-Dimethoxybenzidine

机译：用于油漆和表面涂层制造的有机颜料和染料的潜在健康危害。附录I：化学物质联苯胺，3,3'-二甲基联苯胺和3,3'-二甲氧基联苯胺所提出的染料的拟议规定的科学依据

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摘要

The scientific bases for regulating dyes derived from benzidine (92875), 3,3'-dimethylbenzidine (119937), and 3,3'-dimethoxybenzidine (119904) are presented. Studies of these compounds have demonstrated that benzidine type dyes undergo nearly complete cleavage to known potent human carcinogenic agents through several metabolic and biological pathways, that these metabolites are carcinogenic in human and animal studies, that the toxicity and carcinogenicity of benzidine type dyes has been demonstrated in animals, and that there is a high incidence of bladder cancer among users of benzidine type dyes. Industrial workers were at risk through the inhalation of dye dusts, absorption through skin exposure, and accidental ingestion. Industries involved included dye manufacture, textile finishing, leather working, and paper dyeing. Direct dyes sold for home and craft use that may contain benzidine type dyes were listed by brand name and company or distributor. Commercial trade names of dyes and pigments based on these chemical substances were listed. Chemical identification of benzidine type dyes was described. Alternatives to benzidine type dyes were suggested, and a history of legislative attempts to regulate benzidine type dye production was provided.

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