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首页> 美国政府科技报告 >Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines.
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Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines.

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

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Lymphocytes derived from the peripheral lymph nodes of guinea pigs immunized with RS virus developed delayed hypersensitivity to whole RS virus but not to RS virus but not to RS virus antigens A and B when measured by the in vitro lymphocyte transformation method. Several RS virus strains have been adapted to growth at 28C and 26C in WI-38. These strains demonstrate differences in cytopathic effect and in their ability to induce interferon production. RS virus antigens have been successfully isolated and purified using a new technique,isoelectric focusing. New chromatographic techniques,including the use of Corning CPG-10have been applied to the preparation of RS virus antigens. Two experimental live RS virus vaccines have been evaluated. Both were demonstrated to be safe and immunogenic. Meningococcal Types C and A polysaccharide vaccines have been tested in children. Both vaccines were shown to be non-reactive and immunogenic. Preliminary trials with Pneumococcus Type II polysaccharide vaccine were begun. Early results indicate that the vaccine was non-reactive. Serologic studies are pending.

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