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首页> 美国政府科技报告 >Estriol (Nsc-12 169E) Toxicity of 28 Daily Oral Treatments in Dogs and Monkeys. Effects of 5 Daily Oral Treatments Upon Bsp Retention in Rabbits
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Estriol (Nsc-12 169E) Toxicity of 28 Daily Oral Treatments in Dogs and Monkeys. Effects of 5 Daily Oral Treatments Upon Bsp Retention in Rabbits

机译：雌三醇（Nsc-12 169E）对狗和猴的28种日常口服治疗的毒性。 5种口服每日口服对兔Bsp保留的影响

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Dogs and monkeys treated orally, with 28 daily doses of 7.5, 2.5, and 0.75 mg/kg, survived, 2 monkeys in subnormal, the other animals in good general condition. The monkeys reacted with severe swelling of the anogenital area; male monkeys with edema of the scrotum and of the preputium, female monkeys with protracted estrus. In all monkeys the body weight increased with maximum at the end of the treatment period. Dogs reacted with weight loss and edema of the vulva. Consistent hematological and blood chemical changes did not occur. In all 8 male dogs, the histopathological evaluation showed degeneration of the festes, and in most of them vacuolar changes of the epithelium of the epididymis (6/8), atrophy (6/8) and squamous metaplasia of the prostate (5/8) and prostatitis (3/8). Monkeys and dogs, exhibited a moderate decrease in urinary Na(+) content, early during treatment with 7.5 and 2.5 mg/kg. This change coincided with a moderate decrease in serum Cl in the monkey and a moderate increase in serum Cl(-) in the dog. In rabbits, treatment with 5 daily oral doses of 7.5 mg/kg slightly prolonged BSP retention. (Author)

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