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首页> 美国政府科技报告 >Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-based Drugs. Evidence Report/Technology Assessment Number 196
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Assessment of Thiopurine Methyltransferase Activity in Patients Prescribed Azathioprine or Other Thiopurine-based Drugs. Evidence Report/Technology Assessment Number 196

机译：评估患者使用硫唑嘌呤或其他硫嘌呤类药物中的硫嘌呤甲基转移酶活性。证据报告/技术评估编号196

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The objectives of the assessment was to examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping) or TPMT genotype, to guide thiopurine therapy in chronic autoimmune disease patients, reduces treatment harms. Other objectives included assessing: preanalytic, analytic, and postanalytic requirements for TPMT testing; diagnostic accuracy of TPMT genotyping versus phenotyping; association of thiopurine toxicity with TPMT genotypic or phenotypic status; and costs of testing, care, and treating drug-associated complications. MEDLINE(Trademark), EMBASE(Trademark), and Healthstar were searched from inception to May 2010; the Cochrane Library(Trademark) to October 2009; and BIOSIS(Trademark), Genetics Abstracts, and EconLitTM to May 2009, for English language records. A reviewer screened records, and a second reviewer verified exclusions and subsequent selection of relevant studies. Studies in patients with leukemia and organ transplant were excluded. Additionally, laboratories that provide TPMT analytical services were surveyed to assess means of TPMT testing in practice. Where possible, risk of bias was assessed using standard criteria. Meta-analyses estimated diagnostic sensitivity, and specificity; and odds ratios of associations.

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