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首页> 美国政府科技报告 >Discordant Results from Reverse Sequence Syphilis Screening - Five Laboratories, United States, 2006-2010. Morbidity and Mortality Weekly Report, Vol. 60, No. 5, February 11, 2011
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Discordant Results from Reverse Sequence Syphilis Screening - Five Laboratories, United States, 2006-2010. Morbidity and Mortality Weekly Report, Vol. 60, No. 5, February 11, 2011

机译：反向序列梅毒筛查的不一致结果 - 美国五个实验室，2006-2010。发病率和死亡率周报，Vol。 2011年2月11日，第60期，第5期

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摘要

CDC recommends syphilis serologic screening with a nontreponemal test, such as the rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) test, to identify persons with possible untreated infection; this screening is followed by confirmation using one of several treponemal tests. Recently, the availability of automatable treponemal enzyme and chemiluminescence immunoassays (EIA/CIA) has led some laboratories to adopt a reverse sequence of screening in which a treponemal EIA/CIA is performed first, followed by testing of reactive sera with a nontreponemal test. To better understand the performance of reverse sequence screening for syphilis, CDC analyzed data from five laboratories that used reverse sequence screening during 2006-2010. This report describes the results of that analysis, which indicated that among sera reactive on initial screening with a treponemal EIA/CIA, 56.7% had a nonreactive RPR test. Among these discordant sera, 31.6% also were nonreactive by treponemal testing using Treponema pallidum particle agglutination (TP-PA) or fluorescent treponemal antibody absorbed (FTA-ABS) tests. Among discordant sera, the rate of nonreactive confirmatory treponemal tests was 2.9 times higher in a population with low prevalence of syphilis, suggesting that the low-prevalence population had a higher percentage of false-positive test results.

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