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首页> 美国政府科技报告 >Assessment of Health Impacts of Particulate Matter from Indoor Air Sources Phase I: Development of In Vitro Methodology. Final Report
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Assessment of Health Impacts of Particulate Matter from Indoor Air Sources Phase I: Development of In Vitro Methodology. Final Report

机译：评估室内空气源颗粒物对健康的影响第一阶段：体外方法学的发展。总结报告

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The overall objective of this study was to develop approaches to assess the toxicities of several major indoor particulate matter (PM) source samples by using human in vitro cell models with a focus on inflammatory and oxidative stress responses. In the pilot study, the capacity of extracts from incense PM to stimulate inflammatory marker production in four in vitro human cell models was evaluated. The U937 macrophage cell line was the most sensitive of the test models followed by the NCI-H441 bronchiolar Clara cell line. PM toxicity from cooking activities, candle burning, wood burning, and incense burning was assessed in both cell models. All indoor PM sample source types had some positive response in either or both of the human cell lines with incense producing the largest responses. In further analytical studies, it was determined that incense PM contained high levels of PAHs while wood smoke had lower levels. Incense also was found to contain many other compounds such as vanillin which may contribute to its high toxicity. Wood smoke yielded hydrocarbons containing a series of siloxanes. Cooking PM sample from the stir frying contained mainly hydrocarbons related to the oil used. The candle samples consisted of numerous hydrocarbons such as alkanes and alkenes.

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