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首页> 美国政府科技报告 >NTP Technical Report on the Multigenerational Reproductive Toxicology Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study).
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NTP Technical Report on the Multigenerational Reproductive Toxicology Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study).

机译：关于染料木黄酮（Cas No. 446-72-0）在sprague-Dawley大鼠中的多代生殖毒理学研究的NTp技术报告（饲料研究）。

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Under the conditions of this study, dietary exposure to 500 ppm genistein (approximately 35 mg genistein/kg body weight per day in males and 51 mg/kg per day in females) decreased body weights, accelerated vaginal opening, decreased anogenital distance, and altered estrous cyclicity in females continuously ingesting genistein. Significant decreases in postweaning body weight and decreases in anogenital distance in males were confined to the F(sub 1) generation and were not seen in the similarly exposed F(sub 2) generation. In animals exposed to 500 ppm, there was some evidence for reduced litter size in the F(sub 1) and F(sub 2) generations that were continuously exposed to the test chemical. No other impacts on fertility and no histopathologic lesions were observed in females. The male reproductive tract did not show significant alterations, but increased incidences of hyperplasia of the mammary gland and calcification of renal tubules were observed in continuously exposed 100 and 500 ppm males examined at 20 weeks of age. Weaker effects on the incidences of male mammary gland hyperplasia were observed in 500 ppm males exposed only as adults or exposed only in utero and through lactation. Other than decreased body weight gains in preweaning pups, there was no evidence for a carryover of genistein effects into unexposed generations.

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