首页> 美国政府科技报告 >NTP Technical Report on the Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CAS No. 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether in Male NBR Rats (Inhalation Studie

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NTP Technical Report on the Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CAS No. 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether in Male NBR Rats (Inhalation Studie

机译：NTp技术报告对F344 / N大鼠和B6C3F1小鼠中丙二醇单叔丁基醚（Cas号57018-52-7）的毒理学和癌变研究及丙二醇单叔丁基醚的毒理学研究男性NBR大鼠（吸入研究

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Propylene glycol mono-t-butyl ether is used as a solvent in all-purpose cleaners, inks, and nail polish lacquers. We studied the effects of propylene glycol mono-t-butyl ether on male and female rats and mice to identify potential toxic or cancer-related hazards to humans. We exposed groups of male and female rats and mice to air containing vapors of propylene glycol mono-t-butyl ether at concentrations of 75,300, or 1,200 parts per million (ppm) for 6 hours per day, 5 days a week for 2 years. Untreated control animals were housed in similar exposure chambers but without chemical exposure for comparison. Tissues from more than 40 sites were examined for every animal.

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年度 2004
页码 p.1-316
总页数 316
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicology; Carcinogenesis; Propylene glycols; Ethers; Chemical analysis; Exposure; Laboratory animals; Mice; Rats; Solvents; Hazards; Metabolism; Pathology; Experimental design;

机译：Toxicology;Carcinogenesis;propylene glycols;Ethers;Chemical analysis;Exposure;Laboratory animals;mice;Rats;solvents;Hazards;metabolism;pathology;Experimental design;

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1. Inhalation toxicology and carcinogenesis studies of propylene glycol mono-t-butyl ether in rats and mice. [J] . Doi AM, Roycroft JH, Herbert RA, Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2004,第1期

机译：丙二醇单叔丁基醚在大鼠和小鼠中的吸入毒理学和致癌作用研究。
2. Toxicokinetics of Propylene Glycol Mono-t-Butyl Ether Following Intravenous or Inhalation Exposure in Rats and Mice. [J] . Roycroft J Inhalation toxicology . 2004,第5期

机译：在大鼠和小鼠中静脉或吸入暴露后丙二醇单叔丁基醚的毒代动力学。
3. Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice. [J] . Spencer PJ, Crissman JW, Stott WT, Toxicologic pathology . 2002,第5期

机译：丙二醇单甲醚（PGME）：在Fischer 344大鼠和B6C3F1小鼠中的吸入毒性和致癌性。
4. Derivation of EU-Lowest Concentration of Interest (LCI) of propylene glycol monomethyl ether for the health-based assessment of emission levels from construction products [C] . Choi J, Hoehne D, Mune W, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2019

机译：源自欧盟的最低利益丙二醇单甲醚的浓度（LCI），用于基于健康的建筑产品排放水平评估
5. Experimental and Computational Studies on the Temperature Dependence of Thermal Conductivities for Water, Ethylene Glycol, Glycerol, and Propylene Glycol, Using the Transient Hotwire Method [D] . Alharbi, Salman M. 2018

机译：水，乙二醇，甘油和丙二醇热导流率温度依赖性的实验和计算研究，使用瞬态炎术法
6. Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): inhalation fertility and teratogenicity studies in rats mice and rabbits. [O] . T R Hanley Jr, J T Young, J A John, 1984

机译：乙二醇单甲醚（EGME）和丙二醇单甲醚（PGME）：在大鼠小鼠和兔子中的吸入性生育力和致畸性研究。
7. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1/N Mice (Inhalation Studies) [O] . 2015

机译：关于偏二氯乙烯（Casrn 75-35-4）在F344 / N大鼠和B6C3F1 / N小鼠（吸入研究）中的毒理学和致癌物质研究的技术报告
8. NTP Technical Report on the Toxicology Studies of a Pentabromodiphenyl Ether Mixture (DE-71 (Technical Grade)) (CAS NO. 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture (DE-71 (Technical Grade)) in WISTAR HAN (Crl:WI(Han)) Rats and B6C3F1/N Mice (Gavage Studies). [R] . 2016

机译：NTp技术报告关于五溴二苯醚混合物（DE-71（技术等级））（Cas NO.32534-81-9）在F344 / N大鼠和B6C3F1 / N小鼠中的毒理学研究和五溴二苯醚的毒理学和癌变研究WIsTaR HaN（Crl：WI（Han））大鼠和B6C3F1 / N小鼠（灌胃研究）中的混合物（DE-71（技术级））。

NTP Technical Report on the Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CAS No. 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether in Male NBR Rats (Inhalation Studie

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