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Use of Cis-Epoxyeicosantrienoic Acids and Inhibitors of Soluble Epoxide Hydrolase to Reduce Pulmonary Infiltration by Neutrophils.

机译：使用顺式 - 环氧乙二醇三烯酸和可溶性环氧化物水解酶抑制剂来减少中性粒细胞的肺部浸润。

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It has now been discovered that inhibitors of soluble epoxide hydrolase (sEH) are useful in reducing the severity of or inhibiting the progression of obstructive pulmonary diseases, restrictive airway diseases, and asthma. Administering a cis-epoxyeicosantrienoic acid (EET) in addition to the inhibitor is at least additive, and may be synergistic, in reducing or inhibiting these conditions and diseases, as measured by reduced numbers of neutrophils present in the lung. The inhibitor of sEH may be a nucleic acid, such as a small interfering RNA.

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作者
Hammock, B. D.; Pinkerton, K. E.; Smith, K. R.; Watanabe, T.; Ma, S. J.;
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年度 2004
页码 1-18
总页数 18
原文格式 PDF
正文语种 eng
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关键词
Hydrolases; Patent applications; Inhibitors; Epoxides; Infiltration; Neutrophils; Blood cells; Pulmonary diseases; Asthma; Nucleic acids; Ribonucleic acids; Cis-epoxyeicosantrienoic acids;

机译：水解酶;专利申请;抑制剂;环氧化物;浸润;中性粒细胞;血细胞;肺疾病;哮喘;核酸;核糖核酸;顺式 - 环氧二十碳三烯酸;

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专利

1. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice [J] . Li Dan, Liu Yajin, Zhang Xu, Journal of Molecular and Cellular Cardiology . 2016,第Null期

机译：可溶性环氧化物水解酶的抑制作用通过减少Ldlr（-/-）小鼠中的单核细胞浸润减轻动脉粥样硬化
2. Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways [J] . Dong Xin-wei, Jia Yong-liang, Ge Ling-tian, Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2017,第期

机译：可溶性环氧化物水解酶抑制剂通过抑制p38 / smad3途径降低小鼠中的肺炎蛋白诱导的肺毒性
3. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty AcidAmide Hydrolase Inhibitors [J] . Sean D. Kodani, Debin Wan, Karen M. Wagner, ACS Omega . 2018,第10期

机译：可溶性双环氧水解酶/脂肪酸酰胺水解酶抑制剂的设计和效能
4. A PRACTICAL SYNTHESIS OF KEY CHIRAL EPOXIDE INTERMEDIATES FOR PROTEASE INHIBITORS FROM L-ASCORBIC ACID [C] . Soon Mog So, Sang Min Lee, Kyoung Mee Seol International Carbohydrate Symposium . 2013

机译：L-抗坏血酸蛋白酶抑制剂的关键手性环氧化物中间体的实际合成
5. Characterization Of Novel Epoxide Hydrolase Activities On Epoxy Fatty Acids In Mosquitoes And Examination of How Epoxide Hydrolase Inhibition Affects Mosquito Physiology [D] . Xu, Jiawen 2015

机译：蚊子中环氧脂肪酸新的环氧水解酶活性的表征以及对环氧水解酶抑制作用如何影响蚊子生理的研究
6. Inhibition of Soluble Epoxide Hydrolase Alleviated Atherosclerosis by Reducing Monocyte Infiltration in Ldlr−/− Mice [O] . Dan Li, Yajin Liu, Xu Zhang, -1

机译：通过减少Ldlr-/-小鼠中的单核细胞浸润抑制可溶性环氧化物水解酶缓解了动脉粥样硬化。
7. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response [O] . Keserü, Benjamin, Barbosa-Sicard, Eduardo, Popp, Rüdiger, 2008

机译：环氧二十碳三烯酸和可溶性环氧化物水解酶是决定肺动脉压力和急性缺氧性肺血管收缩反应的因素

Use of Cis-Epoxyeicosantrienoic Acids and Inhibitors of Soluble Epoxide Hydrolase to Reduce Pulmonary Infiltration by Neutrophils.

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