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Vectors and Methods for Immunization Against Norwalk Virus Using Transgenic Plants.

机译：使用转基因植物免疫诺瓦克病毒的载体和方法。

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摘要

The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.

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作者
Hamilton, W. D.; Hellendoorn, K.; Jones, T. D.; Kirk, D. D.; Mason, H. S.;
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年度 2004
页码 1-72
总页数 72
原文格式 PDF
正文语种 eng
中图分类
关键词
Viruses; Immunization; Patent applications; Vectors; Methods; Encoding; Vaccines; Immunology; Norwalk virus; Transgenic plants; Capsid protein virus-like particles; Plant-optimized nucleic acid molecule;

机译：病毒;免疫;专利申请;载体;方法;编码;疫苗;免疫学;诺沃克病毒;转基因植物;衣壳蛋白病毒样颗粒;植物优化的核酸分子;

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专利

1. Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein [J] . Kim Shin-Hee, Chen Shun, Jiang Xi, Virology . 2015,第Null期

机译：在存在或不存在VP2蛋白的情况下表达诺沃克病毒辣椒蛋白的新城疫病毒载体的免疫原性
2. Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein [J] . Kim Shin-Hee, Chen Shun, Jiang Xi, Virology . 2015,第Null期

机译：在存在或不存在VP2蛋白的情况下表达诺沃克病毒衣壳蛋白的新城疫病毒载体的免疫原性
3. An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine. [J] . Alejo D. M., Moraes M. P., Liao X. F., Vaccine . 2013,第18期

机译：腺病毒载体粘膜佐剂增强了用腺病毒载体口蹄疫病毒亚单位疫苗鼻内免疫小鼠的保护。
4. MOLECULAR DETECTION OF NORWALK VIRUSES IN DRINKING WATER BY FILTRATION-ELUTION METHODS USING AN ALTERNATIVE AMINO ACID ELUENT [C] . Vincent R. Hill, Ming-Jing Wu, Radi Hamidjaja, Water quality technology conference . 2002

机译：交替氨基酸洗脱液的洗脱方法分子检测饮用水中诺沃克病毒
5. Molecular cloning and analysis of the genes for cotton palmitoyl-acyl carrier protein thioesterase (PATE) and Delta-12 fatty acid desaturase (FAD2-3) and construction of sense and anti-sense PATE plasmid vectors for altering oilseed composition of transgenic cotton plants. [D] . Nampaisansuk, Mongkol. 2002

机译：棉花棕榈酰基-酰基载体蛋白硫酯酶（PATE）和Delta-12脂肪酸去饱和酶（FAD2-3）的基因的分子克隆和分析，以及用于改变转基因棉花植物油料组成的有义和反义PATE质粒载体的构建。
6. Immunogenicity of Newcastle Disease Virus Vectors Expressing Norwalk Virus Capsid Protein in the Presence or Absence of VP2 Protein [O] . Shin-Hee Kim, Shun Chen, Xi Jiang, -1

机译：在存在或不存在VP2蛋白的情况下表达诺沃克病毒衣壳蛋白的新城疫病毒载体的免疫原性
7. Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein [O] . Kim Shin-Hee, Chen Shun, Jiang Xi, 2015

机译：在存在或不存在VP2蛋白的情况下表达诺沃克病毒衣壳蛋白的新城疫病毒载体的免疫原性
8. Methods of Suppressing Flowering in Transgenic Plants. [R] . Yanofsky, M. F. 2005

机译：抑制转基因植物开花的方法。

Vectors and Methods for Immunization Against Norwalk Virus Using Transgenic Plants.

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