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首页> 美国政府科技报告 >Genetic Evaluation of Extracts of Dow Corning MDF-0107 Foley Catheter Dispersion in the Ames Bacterial Assay, with Cover Letter dated 04/20/1994
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Genetic Evaluation of Extracts of Dow Corning MDF-0107 Foley Catheter Dispersion in the Ames Bacterial Assay, with Cover Letter dated 04/20/1994

机译：Dow Corning mDF-0107 Foley Catheter Dispersion在ames细菌检测中的提取物的遗传评估，附件日期为1994年4月20日

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The test material was evaluated for genetic activity in a microbial assay (Ames, et al., MUTATION RESEARCH 31:347, 1975) with and without the addition of mammalian metabolic activation. Salmonella typhimurium Str. TA-1535, TA-1537, TA-1538, TA-98, and TA-100 were used as indicator organisms. Dimethy1sulfoxide, absolute ethanol, and sterile physiological saline extracts of the test material prepared by continuous rotary shaking (150 rpm/37C/24 hours) in accordance with the U.S.P. Class VI Plastics Method for biological testing of solid materials, were each introduced into the test system at concentrations of extract ranging from 50 to 3.12pl. A Spot Plate Test against each of the indicator organisms was conducted using the extracts directly on the surface of the agar test plates. No evidence of genetic activity was observed.

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